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Mimic of transient ischemic attack by anemia-induced asterixis: A novel differential diagnosis of stroke with critical pitfalls
For stroke diagnosis, little or no attention is paid to asterixis 1, because most cases of asterixis are asymptomatic 2. However, falls due to asterixis have been reported 2,3, which could mimic transient ischemic attack (TIA). On the other hand, anemia has been reported as an independent risk factor for cerebral ischemia 4. Therefore, asterixis and anemia are important in the diagnosis of stroke. Here, we report asterixis of the lower extremities that resembled recurrent TIA of the anterior cerebral artery (ACA) with a tiny asymptomatic callosal infarction in a patient with severe anemia.
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2023 Category: Neurology Authors: Akira Hanazono, Hinako Shimada, Keita Yasuda, Yoshiko Takahashi, Homare Funasaka, Yui Sanpei, Masashiro Sugawara Tags: Case Report Source Type: research

Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders caused by a mutation in the human beta-globin gene. The most common and severe form, Hemoglobin SS (also known as sickle cell anemia, SCA), results from homozygous inheritance of the hemoglobin S mutation of beta globin ( β 6 (glu -> val)) on chromosome 11. This mutation leads to non-covalent hydrophobic polymerization of hemoglobin molecules into rod-like structures within erythrocytes and the hallmark “sickle” shaped red blood cells under conditions of low oxygen saturation, intracellular dehydration, and/or acidosis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2022 Category: Neurology Authors: Christopher Chambliss, Jonathan K. Stiles, Beatrice E. Gee Source Type: research

Brain Magnetic Resonance Imaging and Angiography in Children with Sickle Cell Anaemia in Uganda in a Cross-Sectional Sample
Children with sickle cell anaemia (SCA) are highly susceptible to cerebrovascular injury. We performed brain magnetic resonance imaging and angiography (MRI-MRA) in Ugandan children with SCA to identify structural cerebrovascular abnormalities and examine their relationship to standardized clinical assessments.
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2022 Category: Neurology Authors: Richard Idro, Amelia K. Boehme, Michael Kawooya, Samson K. Lubowa, Deogratias Munube, Paul Bangirana, Robert Opoka, Ezekiel Mupere, Angela Lignelli, Philip Kasirye, Nancy S. Green, Frank J. Minja Source Type: research

Hemoglobin Improvement is Positively Associated with Functional Outcomes in Stroke Patients with Anemia
Anemia is a prevalent concern in geriatric medicine. Previous studies have highlighted the high prevalence and adverse healthcare outcomes of anemia in older adults.1,2 Anemia, defined by the World Health Organization (WHO) as a hemoglobin level below 12 and 13 g/dL in women and men, respectively,3 is common in older adults, and an estimated 13% of older adults over age 70 are anemic.1,4 Moreover, anemia has been associated with poor physical performance and disability, frailty, decreased quality of life, and increased mortality rate in community-dwelling older adults.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ai Shiraishi, Fumihiko Nagano, Takahiro Bise, Sayuri Shimazu Source Type: research

Low Hemoglobin Levels are Associated with Sarcopenia, Dysphagia, and Adverse Rehabilitation Outcomes After Stroke
Anemia and sarcopenia are common concern in geriatric care. There is extensive evidence of an association between adverse health outcomes and anemia.1 –3 Anemia has been associated with poor physical performance and disability, frailty, deterioration in quality of life, and increase in mortality rate in community-dwelling older adults.1,4–6 Concurrently, sarcopenia is common in older adults and is associated with relatively poor outcomes. Appr oximately 10% of community-dwelling older adults are affected by sarcopenia, which is associated with increased risk of falls and fractures, physical dependency, malnutrition, and premature death.
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2020 Category: Neurology Authors: Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Takahiro Bise, Sayuri Shimazu, Ai Shiraishi Source Type: research

Dabigatran-induced chronic progressive immune hemolytic anemia: A case report
We present a case of immune hemolytic anemia (IHA) due to dabigatran use in a 72-year-old male with NVAF.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jin-Hong Gong, Guang-Jun Liu, Feng Zhou, Zhi-Qiang Sun Tags: Case Report Source Type: research

Cerebral Venous Thrombosis after Red Blood Cell Transfusion for the Treatment of Iron Deficiency Anemia
A 57-year-old male presented with generalized seizure who received red blood cell (RBC) transfusion for the treatment of iron deficiency anemia (IDA). Neuroradiological findings revealed cerebral venous thrombosis (CVT) on the left frontal vein. He received anticoagulants, anticonvulsants, and iron supplements. He discharged without any neurological deficit. It should be noted that RBC transfusion might increase the risk of CVT in patients with IDA.
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2019 Category: Neurology Authors: Taku Inada, Nobutake Sadamasa, Ryota Motoie, Norikazu Yamana, Waro Taki Tags: Case Report Source Type: research

The Genetic Landscape of Cerebral Steno-Occlusive Arteriopathy and Stroke in Sickle Cell Anemia
Sickle cell disease (SCD) is one of the most common autosomal recessive diseases in humans, occurring at a frequency of 1 in 365 African-American and 1 in 50 sub-Saharan African births. Despite progress in managing complications of SCD, these remain a major health burden worldwide. Stroke is a common and serious complication of SCD, most often associated with steno-occlusive cerebral arteriopathy, but little is known about its pathogenesis. Transcranial Doppler ultrasonography is currently the only predictive test for future development of stroke in patients with sickle cell anemia and is used to guide preventative treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2018 Category: Neurology Authors: Catherine Amlie-Lefond, Jonathan Flanagan, Julie Kanter, William B. Dobyns Tags: Review Article Source Type: research

Decline in Hemoglobin during Hospitalization May Be Associated with Poor Outcome in Acute Stroke Patients
Anemia upon hospital admission is a known predictor of poor functional outcomes in patients with acute cerebral infarction. However, it remains unclear whether reductions in hemoglobin levels during hospitalization influence stroke outcomes. We investigated the association between in-hospital decline in hemoglobin and poor outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - February 22, 2018 Category: Neurology Authors: Arata Abe, Yuki Sakamoto, Yasuhiro Nishiyama, Satoshi Suda, Kentaro Suzuki, Junya Aoki, Kazumi Kimura Source Type: research

The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T > C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke
Although there is adequate knowledge as to the role of traditional cardiovascular risk factors on stroke incidence, knowledge of other risk factors, particularly genetic ones, is still incomplete.
Source: Journal of Stroke and Cerebrovascular Diseases - February 2, 2018 Category: Neurology Authors: Jorge Escobedo, Emmanuel Paz –Aragón, Luz Helena Vega–Rodríguez, Miguel Ángel Benítez–Sanfeliz, Humberto Estrada–Rodríguez, Evangelina González–Figueroa, María Gabriela Liceaga–Craviotto, Jorge Gutiérrez–Cuevas, Adán Valladares–Sa Source Type: research

Ischemic Stroke Mortality Is More Strongly Associated with Anemia on Admission Than with Underweight Status
We examined the association of weight status and hemoglobin levels with 3-month mortality after ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 27, 2017 Category: Neurology Authors: Satoshi Kubo, Naohisa Hosomi, Naoyuki Hara, Shuichiro Neshige, Takahiro Himeno, Shinichi Takeshima, Kazuhiro Takamatsu, Yutaka Shimoe, Taisei Ota, Hirofumi Maruyama, Toshiho Ohtsuki, Masaru Kuriyama, Masayasu Matsumoto Source Type: research

Posterior Circulation Evaluation in Patients with Sickle Cell Anemia
The objective of our study was to describe the pattern of blood flow velocities in the posterior circulation of patients with SCA and to examine their relationship with findings on magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA).
Source: Journal of Stroke and Cerebrovascular Diseases - January 8, 2016 Category: Neurology Authors: Samuel Ademola Adegoke, Maria Stella Figueiredo, Perla Vicari, Henrique Carrete, Marcos Hideki Idagawa, Ayrton Roberto Massaro, Gisele Sampaio Silva Source Type: research

The Effect of Anemia on the Functional Outcomes of the Stroke Patients and the Efficiency of their Stroke Rehabilitation
There has been limited study focusing on the functional outcomes of stroke patients' after rehabilitation, such as functional improvement and discharge destination, length of stay (LOS), and complication rate.
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2015 Category: Neurology Authors: Tik Chan, Ganesh Ganasekaran Source Type: research

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