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Fatty liver and cerebrovascular disease: plausible association and possible mechanisms
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity and has wide ranging extrahepatic manifestations, including through cardiometabolic pathways. As such, there is growing interest in the impact of NAFLD on cerebrovascular disease and brain health more broadly. In this review, we assess recent research into understanding the association between NAFLD and brain health while highlighting potential clinical implications. Recent findings Mechanistically, NAFLD is characterized by both a proinflammatory and proatherogenic state, which results in vascular inflammation and neurodegenerati...
Source: Current Opinion in Lipidology - December 29, 2021 Category: Lipidology Tags: NUTRITION AND METABOLISM: Edited by Frank M. Sacks and Majken K. Jensen Source Type: research

Adiponectin, lipids and atherosclerosis
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - July 14, 2017 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Nonalcoholic Fatty Liver Disease in Patients with Acute Ischemic Stroke is associated with more severe stroke and worse outcome.
There is a paucity of data regarding the association between non alcoholic fatty liver disease (NAFLD) and acute ischemic stroke. Stroke is largely preventable, so that knowledge of risk factors is essential to achieve reductions in the stroke rate and resulting disease burden.
Source: Journal of Clinical Lipidology - May 10, 2017 Category: Lipidology Authors: Sabry M. Abdeldyem, Tarek Goda, Samy A. Khodeir, Sabry Abou saif, Sherief Abd-Elsalam Source Type: research