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Gender Differences in Atrial Fibrosis and Cardiomyopathy Assessed by Left Atrial Low-Voltage Areas During Catheter Ablation of Atrial Fibrillation
This study aimed to delineate gender differences in the prevalence, predictors, and prognostic impact of left atrial low-voltage areas (LVAs). This observational study included 1,488 consecutive patients who underwent initial ablation for AF. Voltage mapping was performed after pulmonary vein isolation during sinus rhythm.
Source: The American Journal of Cardiology - July 21, 2023 Category: Cardiology Authors: Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Taku Toyoshima, Naoko Higashino, Sho Source Type: research

High-Burden Premature Atrial Contractions Predict New-Onset Atrial Fibrillation After Surgical Septal Myectomy
We examined the correlation between different preoperative PAC burdens and POAF in patients with obstructive hypertrophic cardiomyopathy (OHCM) who underwent surgical treatment. We analyzed 304 consecutively admitted patients with OHCM without previous AF who underwent isolated septal myectomy between January 2015 and December 2018.
Source: The American Journal of Cardiology - May 5, 2023 Category: Cardiology Authors: Yanhai Meng, Changrong Nie, Yanbo Zhang, Changsheng Zhu, Enci Hu, Jigao Shang, Tao Lu, Zining Wu, Shuiyun Wang Source Type: research

Biventricular Noncompaction Cardiomyopathy in a Patient Presenting With a New Cerebrovascular Event
Noncompaction (NC) cardiomyopathy (NCCM) is a rare, genetically heterogeneous cardiomyopathy (CM) caused by failure to compact the intertrabecular recesses of the myocardium. This condition usually affects the apical segment of the left ventricle, yet there are noted basal segment, biventricular, and right ventricular predominant cases. NCCM is largely diagnosed in the pediatric population; however, there is increasing recognition in older patients with heart failure and stroke and patients with arrhythmias.
Source: The American Journal of Cardiology - January 6, 2023 Category: Cardiology Authors: Himani Madnawat, Issam Atallah, Ali Ahmad, Kishore Harjai Source Type: research

Ventricular Septal Myectomy Decreases Long-Term Risk for Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy
Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) and is an important cause of morbidity and embolic stroke. The impact of outflow obstruction and the influence of surgical septal myectomy on the development of new-onset AF has not been well described. Consecutive patients with HCM without previous AF were followed for 5.0 ± 3.6 years for new-onset AF, including 717 with obstruction who did not undergo surgical myectomy (outflow gradients ≥30 mm Hg at rest or after provocation), 555 with nonobstructive HCM (outflow gradients
Source: The American Journal of Cardiology - July 11, 2022 Category: Cardiology Authors: Ethan J. Rowin, Craig Cooper, Richard T. Carrick, Melissa Tsoi, Barry J. Maron, Martin S. Maron Source Type: research

Comparison of Complications and In-Hospital Mortality in Takotsubo (Apical Ballooning/Stress) Cardiomyopathy versus Acute Myocardial Infarction
There are limited data on the incidence of complications and in-hospital outcomes, among patients with Takotsubo cardiomyopathy (TC), as compared to acute myocardial infarction (AMI). From 2007-2014, a retrospective cohort of TC was compared to AMI using the National Inpatient Sample database. Complications were classified as acute heart failure, ventricular arrhythmic, cardiac arrest, high-grade atrioventricular block, mechanical, vascular/access, pericardial, stroke and acute kidney injury. Temporal trends, clinical characteristics and in-hospital outcomes were compared.
Source: The American Journal of Cardiology - July 12, 2020 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Gregory W Barsness, Joerg Herrmann, Nandan S Anavekar, Rajiv Gulati, Abhiram Prasad Source Type: research

Relation of Advanced Interatrial Block to Risk of Atrial Fibrillation and Stroke
Advanced interatrial block (A-IAB) has been associated to atrial fibrillation (AF) and ischemic stroke, raising the question as to whether such patients, even when still in sinus rhythm without documented AF, could benefit from oral anticoagulation. AF and A-IAB are both markers of stroke. The anatomical substrate in both is fibrotic atrial cardiomyopathy, resulting in atrial electromechanical dyssynchrony, dysfunction, and left atrial remodelling, that favour blood stasis and hypercoagulation. Under these conditions thrombogenic cascade may be triggered, resulting in systemic embolization.
Source: The American Journal of Cardiology - March 16, 2020 Category: Cardiology Authors: Antoni Bay és-de-Luna, Manuel Martínez-Sellés, Roberto Elosua, Antoni Bayés-Genís, Guiomar Mendieta, Adrian Baranchuk, Günter Breithardt Source Type: research

The Interaction Among Atrial Thromboembolism, Atrial Fibrillation, and Atrial Cardiomyopathy
I read with interest the timely paper titled “Thromboembolism in the Absence of Atrial Fibrillation” by Smietana et al1 that discusses several highly important but underappreciated contributors to ischemic stroke in patients with and without atrial fibrillation (AF). Several are worthy of further emphasis and/or expansion for your readers, both investigators and clinicians. First is the recognition of the concept of atrial cardiomyopathy.2 Atrial cardiomyopathy may be a cause and/or consequence of AF; can vary with the etiology, duration, number, and severity of associated comorbidities as well as the amount of AF pres...
Source: The American Journal of Cardiology - August 1, 2019 Category: Cardiology Authors: James A. Reiffel Source Type: research

Thromboembolism In The Absence Of Atrial Fibrillation
Atrial fibrillation (AF) is associated with thrombus formation in the left atrial appendage (LAA) and systemic embolic events including ischemic stroke. Cardiogenic thromboembolism can also occur in the absence of clinical AF as a result of various pathological conditions affecting the endocardium. The inconsistent temporal relation between AF and ischemic events has stimulated exploration for factors other than clinical AF that contribute to thromboembolism. These include sub-clinical AF, a thrombogenic atrial cardiomyopathy, LAA dysfunction and embolism from other sources.
Source: The American Journal of Cardiology - April 23, 2019 Category: Cardiology Authors: Jeffrey Smietana, Anna Plitt, Jonathan L. Halperin Source Type: research

Extremely low prevalence of Takotsubo cardiomyopathy and transient cardiac dysfunction in stroke patients with T-wave abnormalities
Stone et al. studied an important association about the presence of cerebral T-waves in 800 patients with ischemic stroke1. They demonstrated that about 17 (2.1%) patients presenting with stroke exhibited cerebral T-waves and of those, only 3 patients (18%) with T-wave abnormality have transient systolic dysfunction on echocardiography. Thus overall, only 0.0037% (3 of 800) patients developed Takotsubo cardiomyopathy (TC) in the study group of patients with stroke.1
Source: The American Journal of Cardiology - January 9, 2019 Category: Cardiology Authors: Lovely Chhabra, Nauman Khalid, Pooja Sareen Source Type: research

Comparison of In-Hospital Outcomes of Patients With-Versus-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy [ICM] versus nonischemic cardiomyopathy) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary end point was the effect of ICM on in-hospital mortality. Secondary end points included periprocedural vascular complications requiring surgery, postoperative myocardial infarction, stroke, and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - November 20, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Subahi, Oluwole Adegbala, Ahmed S. Yassin, Emmanuel Akintoye, Ahmed Abdulrahman, Abdelrahman Ahmed, Adedotun Alade, Mohit Pahuja, Luis Afonso Source Type: research

Comparison of In-hospital Outcomes of Patients With-vs-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy (IC) vs. non-ischemic cardiomyopathy (NIC)) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample (NIS) database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary endpoint was the effect of ICM on in-hospital mortality. Secondary endpoints included peri-procedural vascular complications requiring surgery, post-operative myocardial infarction, stroke and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - November 20, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Subahi, Oluwole Adegbala, Ahmed S Yassin, Emmanuel Akintoye, Ahmed Abdulrahman, Abdelrahman Ahmed, Adedotun Alade, Mohit Pahuja, Luis Afonso Source Type: research

Occurrence and Natural History of Clinically Silent Episodes of Atrial Fibrillation in Hypertrophic Cardiomyopathy
Overt symptomatic atrial fibrillation (AF) occurs in over 20% of hypertrophic cardiomyopathy (HC) patients leading to impaired quality of life, loss of productivity, and the risk for embolic stroke. However, the overall burden presented by AF in the HC population is unresolved due to the unknown frequency of silent asymptomatic episodes that do not necessarily achieve clinical recognition, but nevertheless may have important disease-related implications. Therefore, stored electrograms were analyzed retrospectively for AF in 75 consecutive HC patients (without prior AF history) implanted with dual chamber cardioverter-defibrillators (ICD).
Source: The American Journal of Cardiology - March 14, 2017 Category: Cardiology Authors: Ethan J. Rowin, Alexander Orfanos, Mark Estes, Wendy Wang, Mark S. Link, Martin S. Maron, Barry J. Maron Source Type: research

Prognostic Implications of Left Ventricular Scar Determined by Late Gadolinium Enhanced Cardiac Magnetic Resonance in Patients with Atrial Fibrillation
Left ventricular (LV) scar identified by late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) is associated with adverse outcomes in coronary artery disease (CAD) and cardiomyopathies. We sought to determine the prognostic significance of LV-LGE in atrial fibrillation (AF). We studied 778 consecutive patients referred for radiofrequency ablation of AF who underwent CMR. Patients with CAD, prior myocardial infarction (MI), or hypertrophic or dilated cardiomyopathy were excluded. The endpoints of interest were major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of cardiovascular death,...
Source: The American Journal of Cardiology - July 17, 2016 Category: Cardiology Authors: Promporn Suksaranjit, Christopher J. McGann, Nazem Akoum, Joseph Biskupiak, Gregory J. Stoddard, Eugene G. Kholmovski, Leenhapong Navaravong, Allen Rassa, Erik Bieging, Lowell Chang, Imran Haider, Nassir F. Marrouche, Brent D. Wilson Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-Term Risk of Cardiac Death in Patients wtih Hypertrophic Cardiomyopathy
The Objective of this study is to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy (HC). 1004 consecutive patients with HC and a recorded standard ECG (64% men, mean age 50±16 years) were evaluated at 4 Italian centres. The study end-points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest) and major cardiovascular events (including SCD or surrogates and death due to heart failure, cardioembolic stroke or heart transplantation).
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Source Type: research

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