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Case report: Acute vestibular syndrome and cerebellitis in anti-Yo paraneoplastic syndrome
We report three patients evaluated over the past decade with an acute AVS along with subtle downbeat nystagmus (DBN), followed by dysarthria and progressive truncal and limb ataxia, as well as increasing DBN intensity.MethodsAll patients underwent neurologic examination, video-oculography, MRI, serum cancer markers, spinal fluid examination, paraneoplastic panel testing, and oncologic workup. With a consolidated diagnosis of cancer/paraneoplastic syndrome, we treated with plasma exchange (PLEX), high-dose steroids, surgery, and oncologic investigation. We additionally provided oncotherapy in one out of three patients.Resul...
Source: Frontiers in Neurology - August 26, 2022 Category: Neurology Source Type: research

Tumor Embolism Through Right-to-Left Shunt Due to Venous Invasion of Esophageal Carcinoma
A 69-year-old man was admitted to the hospital with right hemiparesis and global aphasia. Perfusion computed tomography imaging revealed ischemic penumbra in the middle cerebral artery territory. Angiography showed left middle cerebral artery occlusion. Mechanical thrombectomy with one pass was performed, and successful recanalization was obtained. Embolic material was retrieved; it contained tumor fragments with atypical keratinizing squamous cell carcinoma. Contrast computed tomography imaging indicated tumor invasion into the superior vena cava, and contrast transcranial Doppler indicated the presence of a right-to-left...
Source: Journal of Stroke and Cerebrovascular Diseases - October 1, 2020 Category: Neurology Authors: Suguru Araki, Kota Maekawa, Kazuto Kobayashi, Takanori Sano, Tadashi Yabana, Masunari Shibata, Fumitaka Miya Tags: Case Report Source Type: research

Gas Embolic Stroke Secondary to Bowel Infarction
A 69-year-old gentleman with metastatic esophageal adenocarcinoma presented with acute abdominal pain to the emergency medicine department and subsequently developed an acute left hemiplegia while in the resuscitation unit. An unenhanced computed tomography (CT) scan of the head showed right frontal cerebral gas emboli while an unenhanced CT scan of the abdomen and pelvis showed extensive portal venous gas and pneumatosis intestinalis, presumed secondary to bowel infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - November 16, 2015 Category: Neurology Authors: Dhruv Parikh, Joe Joseph Leyon, Swarupsinh Chavda Tags: Case Studies Source Type: research

An Unusual Cause Of Recurrent Ischemic Stroke: Trousseau's Syndrome From Gastric Cancer (P4.231)
CONCLUSIONS: Trousseau’s Syndrome must be considered in those presenting with recurrent strokes with an otherwise negative embolic work up especially in the elderly and those with cancer risk factors. It must prompt the clinician to look for an associated malignancy.Disclosure: Dr. JADEJA has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Soetanto has nothing to disclose. Dr. Nalleballe has nothing to disclose. Dr. DeNiro has nothing to disclose. Dr. Qureshi has nothing to disclose. Dr. Graber has received personal compensation for activities with Stemedica Inc., Novocure Inc., and Biogen Idec.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Jadeja, N., Johnson, J., Soetanto, A., Nalleballe, K., DeNiro, L., Qureshi, I., Graber, J. Tags: Neuro-oncology: Paraneoplastic Disorders Source Type: research

A Case Series Of Non-Bacterial Thrombotic Endocarditis Associated With Gynecological Malignancies (P6.248)
Conclusions:NBTE is an important ischemic stroke mechanism. We have reported three cases where the underlying malignancy was gynecological (endometrial, ovarian, and cervical). In the first two cases, the malignancy was discovered during the investigations for the stroke mechanism, while the third had a known underlying malignancy. This series highlights the need to consider gynecological malignancies as an underlying cause of stroke in young women; and that the ischemic event can occur prior to the malignancy diagnosis.Disclosure: Dr. Schabas has nothing to disclose. Dr.Teal has received personal compensation for activiti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schabas, A., Teal, P., Yip, S., Mann, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Analysis of Comorbidities in Ischemic Stroke Patients (P6.278)
CONCLUSIONS: The results indicate evidence of comorbid correlations with patients’ symptoms. A follow-up analysis using the Charlson comorbidity index will provide a method for classifying comorbidity. This will provide a simple, readily applicable and valid method of estimating risk of death from comorbidities in ischemic stroke for use in longitudinal studies and in outcomes research in ischemic stroke. This may provide a valid prognostic indicator for ischemic stroke.Study Supported by: GHSDisclosure: Dr. Cochran has nothing to disclose. Dr. Chaves has nothing to disclose. Dr. Fulmer has nothing to disclose. Dr. B...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Cochran, T., Chaves, J., Fulmer, E., Blackhurst, D., Sternberg, S., Leacock, R., Nathaniel, T. Tags: Cerebrovascular Disease and Interventional Neurology: Risk Factors Source Type: research