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Real-World Study Confirms Benefit of XARELTO ® (rivaroxaban) for Secondary Prevention of Venous Thromboembolism in Cancer Patients
TITUSVILLE, NJ, December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced observational data from eight years of clinical practice showing that the oral Factor Xa inhibitor XARELTO® (rivaroxaban) is associated with comparable effectiveness and safety to the Factor Xa inhibitor apixaban for the treatment of cancer-associated thromboembolism (CAT) in a broad cohort of patients with various cancer types. Patients with CAT are at a higher risk of venous thromboembolism (VTE), which is the second-leading cause of death in people with cancer.1Data from the Observational Study in Cancer-A...
Source: Johnson and Johnson - December 9, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

Effects of neoadjuvant chemo or chemoradiotherapy for oesophageal cancer on perioperative haemodynamics: A prospective cohort study within a randomised clinical trial
CONCLUSION: Neoadjuvant chemoradiotherapy for oesophageal or gastrooesophageal junction cancer seems to induce only a marginal negative effect on cardiac function compared with neoadjuvant chemotherapy. This difference did not remain when patients’ haemodynamics were challenged by surgery. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01362127.
Source: European Journal of Anaesthesiology - August 3, 2016 Category: Anesthesiology Tags: Cardiovascular physiology Source Type: research

Oesophageal Doppler and calibrated pulse contour analysis are not interchangeable within a goal-directed haemodynamic algorithm in major gynaecological surgery
Conclusions Despite a similar precision, ODM and PCA were not interchangeable with regard to measuring SV changes within a goal-directed haemodynamic algorithm. A decrease in interchangeability coincided with increasing NE levels and greater changes of MAP to a fluid challenge.
Source: British Journal of Anaesthesia - October 17, 2014 Category: Anesthesiology Authors: Feldheiser, A., Hunsicker, O., Krebbel, H., Weimann, K., Kaufner, L., Wernecke, K.- D., Spies, C. Tags: Cardiovascular Source Type: research

Effects of Catecholamines on Microcirculation During General Inhalation Anesthesia
Conclusions: During general anesthesia with sevoflurane, the infusion of clinical dosages of norepinephrine and dobutamine did not alter sublingual perfusion, although the expected systemic hemodynamic alterations were induced.
Source: Journal of Cardiothoracic and Vascular Anesthesia - August 22, 2013 Category: Anesthesiology Authors: Paolo Chiarandini, Livia Pompei, Maria Gabriella Costa, Luigi Vetrugno, Fortunato Ronga, Roberta Contin, Fabio Rosa, Giorgio Della Rocca Tags: Original Article Source Type: research

Balanced crystalloid compared with balanced colloid solution using a goal-directed haemodynamic algorithm
Conclusions Using a goal-directed haemodynamic algorithm to optimize stroke volume, a balanced HES solution is associated with better haemodynamic stability and reduced need for fresh-frozen plasma. There were no signs of renal impairment by colloid solutions when fluid administration is targeted to optimize cardiac preload.
Source: British Journal of Anaesthesia - January 14, 2013 Category: Anesthesiology Authors: Feldheiser, A., Pavlova, V., Bonomo, T., Jones, A., Fotopoulou, C., Sehouli, J., Wernecke, K.- D., Spies, C. Tags: Clinical Practice Source Type: research