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HspB8 is Neuroprotective during Oxygen Glucose Deprivation and Reperfusion.
In conclusion, our data demonstrated that increased HspB8 expression and its nuclear shift in mouse N2A neuroblastoma cells protected against I/R injury, resulting in reduced apoptosis with the decrease of the release of cytochrome c from mitochondria to cytosol. Therefore, HspB8 might play a fundamental role in opposing and alleviating I/R injury in primary myocardial cells, and it may constitute a new therapeutic target for cerebral ischemic diseases. PMID: 25557374 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - January 2, 2015 Category: Neurology Authors: Yang B, Zhang H, Mo X, Xiao H, Hu Z Tags: Curr Neurovasc Res Source Type: research

Blockade of Ser16-Hsp20 Phosphorylation Attenuates Neuroprotection Dependent Upon Bcl-2 and Bax.
In conclusion, our data demonstrated that increased Hsp20 and Hsp20 (S16D) expression in mouse N2A neuroblastoma cells protected against ischemia-reperfusion injury, the neuroprotective mechanism may be related to regulate Bcl-2 and Bax expression. However, blockade of Ser16-Hsp20 phosphorylation attenuated the neuroprotective effects of Hsp20. Therefore, Hsp20 and factors that contribute to regulation of phosphorylation on Ser16 of Hsp20 are potential new therapeutic targets for the treatment of cerebral ischemia-reperfusion injury. PMID: 23713735 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - May 24, 2013 Category: Neurology Authors: Zeng L, Tan J, Lu W, Hu Z Tags: Curr Neurovasc Res Source Type: research