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Tracers progress for positron emission tomography imaging of glial-related disease
J Biomed Res. 2022 Jun 28:1-15. doi: 10.7555/JBR.36.20220017. Online ahead of print.ABSTRACTGlial cells play an essential part in the neuron system. They can not only serve as structural blocks in the human brain but also participate in many biological processes. Extensive studies have shown that astrocytes and microglia play an important role in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, as well as glioma, epilepsy, ischemic stroke, and infections. Positron emission tomography is a functional imaging technique providing molecular-level information before anatomic ch...
Source: Biomed Res - September 22, 2022 Category: Research Authors: Haoran Jia Tianwu Xie Source Type: research

The cerebral microvasculature: Basic and clinical perspectives on stroke and glioma
AbstractMicrovascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed in this review, the molecular and cellular components within the microcirculation orchestrate critical processes to establish functional capillary beds, including organization of endothelial cell (EC) polarity, guiding investment of vascular pericytes (PCs), and building the specialized extracellular matrix (ECM) that comprises the vascular basement membrane (vBM). Herein, we further discuss the unique features of ...
Source: Microcirculation - November 23, 2020 Category: Research Authors: Maruf M. Hoque, Hanaa Abdelazim, Clifton Jenkins ‐Houk, Dawn Wright, Biraj M. Patel, John C. Chappell Tags: INVITED REVIEWS Source Type: research

The Cerebral Microvasculature: Basic and Clinical Perspectives on Stroke and Glioma
AbstractMicrovascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed in this review, the molecular and cellular components within the microcirculation orchestrate critical processes to establish functional capillary beds, including organization of endothelial cell (EC) polarity, guiding investment of vascular pericytes (PCs), and building the specialized extracellular matrix (ECM) that comprises the vascular basement membrane (vBM). Herein, we further discuss the unique features of ...
Source: Microcirculation - November 10, 2020 Category: Research Authors: Maruf M. Hoque, Hanaa Abdelazim, Clifton Jenkins ‐Houk, Dawn Wright, Biraj M. Patel, John C. Chappell Tags: INVITED REVIEW Source Type: research