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Neurofilaments: a key new biomarker for clinicians. Part 2: Neurofilaments, an asset beyond neurodegenerative diseases
This article completes the first part, in which we presented the interest of NfL in the context of neurodegenerative diseases. Here we focus our review on other clinical contexts of neurological injury (such as traumatic brain injury, multiple sclerosis, stroke, and cancer) and present the potential value of NfL assay in the management of these patients, for both diagnosis and prognosis. We also discuss the added value of the NfL assay compared to other biomarkers commonly used in the described clinical situations.PMID:36453743 | DOI:10.1684/abc.2022.1758
Source: Annales de Biologie Clinique - December 1, 2022 Category: Biochemistry Authors: Constance Delaby Olivier Bousiges Damien Bouvier Catherine Fill ée Anthony Fourier Étienne Mondésert Nicolas Nezry Souheil Omar Isabelle Quadrio Benoit Rucheton Susanna Schraen-Maschke Vincent van Pesch St éphanie Vicca Sylvain Lehmann Aur élie Bedel Source Type: research
Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF- κB signaling pathway
CONCLUSIONS: These findings indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.PMID:36447154 | DOI:10.1186/s10020-022-00573-7
Source: Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Zining Yu Guangjun Su Limei Zhang Gaigai Liu Yonggang Zhou Shicai Fang Qian Zhang Tianyun Wang Cheng Huang Zhihua Huang Liangdong Li Source Type: research
