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Specialty: Cancer & Oncology
Condition: Stroke
Cancer: Brain Cancers
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Total 93 results found since Jan 2013.
Identification of cell death-related biomarkers and immune infiltration in ischemic stroke between male and female patients
CONCLUSION: These findings contribute to a better knowledge of immune cell infiltration and their corresponding molecular mechanisms of cell death and offer distinct clinically relevant biological targets for IS patients of different genders.PMID:37435058 | PMC:PMC10332266 | DOI:10.3389/fimmu.2023.1164742
Source: Cancer Control - July 12, 2023 Category: Cancer & Oncology Authors: Wenli Chen Yuanfang Chen Liting Wu Yue Gao Hangju Zhu Ye Li Xinyu Ji Ziyi Wang Wen Wang Lei Han Baoli Zhu Hongxing Wang Ming Xu Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case –control and cross-sectional analysis
ConclusionsStroke prevalence is increased in long-surviving PBT patients treated with cranial RT.Implications for cancer survivorsCV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.
Source: Journal of Cancer Survivorship - May 5, 2023 Category: Cancer & Oncology Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case-control and cross-sectional analysis
CONCLUSIONS: Stroke prevalence is increased in long-surviving PBT patients treated with cranial RT.IMPLICATIONS FOR CANCER SURVIVORS: CV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.PMID:37142871 | DOI:10.1007/s11764-023-01350-z
Source: Cancer Control - May 4, 2023 Category: Cancer & Oncology Authors: Mar ía-José Ibáñez-Juliá Alberto Picca Delphine Leclercq Giulia Berzero Julian Jacob Lo ïc Feuvret Charlotte Rosso Cristina Birzu Agusti Alentorn Marc Sanson Camille Tafani Flavie Bompaire Luis Bataller Kh ê Hoang-Xuan Jean-Yves Delattre Dimitri Ps Source Type: research
Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation
CONCLUSION: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.PMID:37096314 | DOI:10.3346/jkms.2023.38.e159
Source: Cancer Control - April 25, 2023 Category: Cancer & Oncology Authors: Jaelim Cho Heeseon Jang Young Noh Seung-Koo Lee Sang-Baek Koh Sun-Young Kim Changsoo Kim Source Type: research
The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms
Int J Mol Sci. 2023 Mar 28;24(7):6328. doi: 10.3390/ijms24076328.ABSTRACTNeuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing brain damage and contributing to the onset and progression of various brain diseases. Therefore, understanding neuroinflammation mechanisms and developing strategies to control them is crucial for treating brain diseases. Studies have shown that neuroinflammation plays a vital role in the progression of neurodegenerative diseases, such as Alzheimer'...
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Ming-Chang Chiang Tsung-Yu Tsai Chieh-Ju Wang Source Type: research
Dietary diversity and risk of late-life disabling dementia in middle-aged and older adults
CONCLUSIONS: Our findings indicate that eating a variety of foods may prevent disabling dementia only among women. Thus, the habit of consuming a variety of food items has important public health implications for women.PMID:36863290 | DOI:10.1016/j.clnu.2023.02.002
Source: Cancer Control - March 2, 2023 Category: Cancer & Oncology Authors: Rei Otsuka Shu Zhang Hikaru Ihira Norie Sawada Manami Inoue Kazumasa Yamagishi Nobufumi Yasuda Shoichiro Tsugane Source Type: research
Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
In conclusion, the mutual regulation of autophagy and inflammation in ICH is worth exploring. The control of inflammation by autophagy will hopefully prove to be an essential treatment target for ICH.PMID:36726453 | PMC:PMC9884704 | DOI:10.3389/fncel.2022.1036313
Source: Cancer Control - February 2, 2023 Category: Cancer & Oncology Authors: Kaijing Fu Weilin Xu Cameron Lenahan Yong Mo Jing Wen Teng Deng Qianrong Huang Fangzhou Guo Ligen Mo Jun Yan Source Type: research
Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents
Fitoterapia. 2022 Dec 20:105398. doi: 10.1016/j.fitote.2022.105398. Online ahead of print.ABSTRACTPiper longum has a specific aroma and spicy taste. In addition to edible value, current studies have shown that piper longum also has pharmacological activities such as anti-platelet aggregation, anti-inflammation, anti-cancer, anti-diabetes and anti-depression. Piperlongumine is an alkaloid isolated from Piper longum. Based on our previous studies, four Piperlongumine analogs were synthesized, and their anti-platelet aggregation activities were evaluated. Among them, compound 8 has the strongest anti-platelet aggregation acti...
Source: Cancer Control - December 23, 2022 Category: Cancer & Oncology Authors: Tan Lijuan Cao Xiaolu Wan Xin He Yuying Lan Xi Yang Xiliang Wang Ting Min Zhenli Zou Yu Source Type: research
Ischemic stroke in a patient with EGFR ‐mutated non–small‐cell lung cancer after treatment with ramucirumab
This article presents the case of a non–small-cell lun g cancer patient who experienced a new ischemic stroke after treatment with ramucirumab. The findings suggest that further studies may be necessary to investigate the relationship between ramucirumab and the risk of ischemic stroke.
Source: Thoracic Cancer - October 29, 2022 Category: Cancer & Oncology Authors: Guo ‐Yu Chen,
Wen‐Chien Cheng,
Chih‐Yen Tu Tags: CASE REPORT Source Type: research
Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins (Basel). 2022 Oct 11;14(10):696. doi: 10.3390/toxins14100696.ABSTRACTThe importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop ...
Source: Cancer Control - October 26, 2022 Category: Cancer & Oncology Authors: Pedro Henrique de Oliveira Cardoso Ana Paula de Ara újo Boleti Patr ícia Souza E Silva Lincoln Takashi Hota Mukoyama Alexya Sandim Guindo Luiz Filipe Ramalho Nunes de Moraes Caio Fernando Ramalho de Oliveira Maria Ligia Rodrigues Macedo Cristiano Marcel Source Type: research
Can mental practice adjunct in the recovery of motor function in the upper limbs after stroke? A systematic review and meta-analysis
CONCLUSION: Current evidence does not support the use of the mental practice to increase the recovery of the upper limb after stroke, although the evidence is conflicting for some aspects of the technique.PMID:36267434 | PMC:PMC9578308 | DOI:10.4103/bc.bc_28_22
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Danielle Aprigio Juliana Bittencourt Maria Ramim Victor Marinho Igor Brauns Isabelle Fernandes Pedro Ribeiro Bruna Velasques Ana Catarina Alves E Silva Source Type: research
Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration
The objectives of this study were to (1) determine the effect of MMP-12 suppression by shRNA-mediated gene silencing on neurological/functional recovery, (2) establish the optimal timing of MMP-12shRNA treatment that provides maximum therapeutic benefit, (3) compare the effectiveness of acute versus chronic MMP-12 suppression, and (4) evaluate potential sex-related differences in treatment outcomes. Young male and female Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion and reperfusion. Cohorts of rats were administered either MMP-12shRNA or scrambled shRNA sequence (control) expressing plasm...
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Siva Reddy Challa Koteswara Rao Nalamolu Casimir A Fornal Billy C Wang Ryan C Martin Elsa A Olson Ammar L Ujjainwala David M Pinson Jeffrey D Klopfenstein Krishna Kumar Veeravalli Source Type: research
Role of Serum Homocysteine and Outcome in Patients With Traumatic Brain Injury
Conclusion The study concluded that patients who had suffered from a TBI had significantly higher serum Hcy levels. Furthermore, the study highlighted that the patients with the worst outcomes had more severe hyperhomocysteinemia (HHcy) than those with better outcomes. Moreover, patients with low GOS scores were more likely to have HHcy.PMID:36237797 | PMC:PMC9548089 | DOI:10.7759/cureus.28968
Source: Cancer Control - October 14, 2022 Category: Cancer & Oncology Authors: Humayoun Amini Hewad Hewadmal Sayed Farhad Rasuli Chowdhury S Shahriar Abdul Fattah Hariharan Kavanoor Sridhar Marjan Khan Sadaf Bhat Abdul Subhan Talpur Laila Tul Qadar Source Type: research
Recent advances in drug delivery and targeting to the brain
J Control Release. 2022 Aug 31:S0168-3659(22)00574-0. doi: 10.1016/j.jconrel.2022.08.051. Online ahead of print.ABSTRACTOur body keeps separating the toxic chemicals in the blood from the brain. A significant number of drugs do not enter the central nervous system (CNS) due to the blood-brain barrier (BBB). Certain diseases, such as tumor growth and stroke, are known to increase the permeability of the BBB. However, the heterogeneity of this permeation makes it difficult and unpredictable to transport drugs to the brain. In recent years, research has been directed toward increasing drug penetration inside the brain, and na...
Source: Cancer Control - September 3, 2022 Category: Cancer & Oncology Authors: Bharti Sethi Virender Kumar Kalika Mahato Donald W Coulter Ram I Mahato Source Type: research
Neuroprotective effects of tannic acid in the postischemic brain via direct chelation of Zn < sup > 2 < /sup >
Anim Cells Syst (Seoul). 2022 Aug 19;26(4):183-191. doi: 10.1080/19768354.2022.2113915. eCollection 2022.ABSTRACTTannic acid (TA) is a polyphenolic compound that exerts protective effects under pathological conditions. The diverse mechanisms of TA can exert beneficial anti-oxidative, anti-inflammatory, and anti-cancer effects. Herein, we reported that TA affords robust neuroprotection in an animal model of stroke (transient middle cerebral artery occlusion; tMCAO) and exhibits Zn2+-chelating and anti-oxidative effects in primary cortical neurons. Following tMCAO induction, intravenous administration of TA (5 mg/kg) suppres...
Source: Cancer Control - September 1, 2022 Category: Cancer & Oncology Authors: Seung Woo Kim Da Bin Kim Hong Seok Kim Source Type: research
