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The novel function of bexarotene for neurological diseases
Ageing Res Rev. 2023 Jul 24:102021. doi: 10.1016/j.arr.2023.102021. Online ahead of print.ABSTRACTBexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. However, it has also demonstrated promising therapeutic potential for neurological diseases such as stroke, traumatic brain injury, Parkinson's disease, and particularly Alzheimer's disease(AD). In AD, bexarotene inhibits the production and aggregation of amyloid β (Aβ), activates Liver X Receptor/RXR heterodimers to increase lipidated apolipoprotein E to remove Aβ, mitigates the negative impact of Aβ, regulates neuroinf...
Source: Ageing Research Reviews - July 26, 2023 Category: Genetics & Stem Cells Authors: Yangtao Liu Pengwei Wang Guofang Jin Peijie Shi Yonghui Zhao Jiayi Guo Yaling Yin Qianhang Shao Peng Li Pengfei Yang Source Type: research