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The novel function of bexarotene for neurological diseases
Ageing Res Rev. 2023 Jul 24:102021. doi: 10.1016/j.arr.2023.102021. Online ahead of print.ABSTRACTBexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. However, it has also demonstrated promising therapeutic potential for neurological diseases such as stroke, traumatic brain injury, Parkinson's disease, and particularly Alzheimer's disease(AD). In AD, bexarotene inhibits the production and aggregation of amyloid β (Aβ), activates Liver X Receptor/RXR heterodimers to increase lipidated apolipoprotein E to remove Aβ, mitigates the negative impact of Aβ, regulates neuroinf...
Source: Ageing Research Reviews - July 26, 2023 Category: Genetics & Stem Cells Authors: Yangtao Liu Pengwei Wang Guofang Jin Peijie Shi Yonghui Zhao Jiayi Guo Yaling Yin Qianhang Shao Peng Li Pengfei Yang Source Type: research

Morbidity and Causes of Death in Patients with Cutaneous T-cell Lymphoma in Finland.
Abstract Cutaneous T-cell lymphomas (CTCL), especially mycosis fungoides, can be considered as a state of longstanding low-grade systemic inflammation. Many studies have focused on secondary cancers with CTCL, but information about comorbidities is limited. A total of 144 patients with CTCL at Helsinki University Central Hospital during 2005 to 2015 were studied to determine associated comorbidities and causes of death in this cohort. Compared with an age-standardized control population, the prevalence of type 2 diabetes mellitus was increased among patients with CTCL with no link to obesity. Patients with CTCL ha...
Source: Acta Dermato-Venereologica - February 7, 2017 Category: Dermatology Authors: Väkevä L, Lipsanen T, Sintonen H, Ranki A Tags: Acta Derm Venereol Source Type: research

Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis.
In conclusion, patients with MF and parapsoriasis have an increased RR of AMI or stroke within the first 5 years of follow-up. PMID: 26576854 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - November 18, 2015 Category: Dermatology Authors: Lindahl LM, Heide-Jørgensen U, Pedersen L, Sørensen HT, Iversen L Tags: Acta Derm Venereol Source Type: research