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Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Smoking Causes More Kinds Of Deaths Than We Ever Thought
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and says an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use. The study by the American Cancer Society and several universities, published in Thursday's New England Journal of Medicine, looks beyond lung cancer, heart disease and other conditions already tied to smoking, and the 480,000 U.S. deaths attributed to them each year. "Smokers die, on average, more than a decade before nonsmokers," and in the U.S., smoking accounts for one of every five deaths, Dr. ...
Source: Science - The Huffington Post - February 12, 2015 Category: Science Source Type: news

Inactivity 'twice as deadly' as obesity
Conclusion This study’s strengths included its large size and long follow-up period. Researchers also took into account a large number of factors (called confounders) that might have influenced the risk of death, such as diet, smoking history and alcohol intake, although it is still possible that both measured and unmeasured confounders influenced mortality rates. The study had one important limitation. It only measured people’s BMI (calculated by combining their weight and height) and their physical activity once, at the start of the study. It is quite possible that people’s BMI changed over time, and that this wou...
Source: NHS News Feed - January 15, 2015 Category: Consumer Health News Source Type: news

Parental smoking 'ages' children’s arteries
ConclusionOverall, this secondary analysis study provides preliminary evidence of the effects of parental passive smoking on the artery walls of children and adolescents in adulthood. The researchers attempted to adjust for potential factors that could influence risk (confounders), such as: age sex height weight smoking status physical activity levels alcohol consumption schooling level of the parent(s)In their analysis, they also took into consideration cardiovascular risk factors of the participants in adulthood. There are some limitations to the study, which are worth noting. Parental smoking status was self-re...
Source: NHS News Feed - March 5, 2014 Category: Consumer Health News Tags: Heart/lungs Pregnancy/child Source Type: news

Five-year 'death test' provides few answers
ConclusionThis large population-based study was able to show which people were at increased risk of dying from cardiovascular, cancer or other causes over a five-year period. However, the researchers could not predict which illness a person may be at higher risk of getting or provide an opportunity for targeted prevention or treatment strategies. Strengths of the study include the large sample size and the fact participants were taken from the general population. The results also remained statistically significant after adjusting for age, sex, current disease and many other recognised indicators of chronic disease.However,...
Source: NHS News Feed - February 26, 2014 Category: Consumer Health News Tags: Heart/lungs Cancer Diabetes Medical practice Source Type: news