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CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell-cell interactions in the pathophysiology of neurological disease
Cell Mol Life Sci. 2022 Mar 4;79(3):172. doi: 10.1007/s00018-022-04185-6.ABSTRACTNeuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, maturation and synaptic refinement. The proteinase inhibitor may function both independently and through tPA-dependent mechanisms. Herein, we discuss the recent evidence regarding the role of neuroserpin in healthy and diseased conditions and highlight the participation of the serpin in various c...
Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2022 Category: Cytology Authors: Angela Godinez Rashi Rajput Nitin Chitranshi Veer Gupta Devaraj Basavarajappa Samridhi Sharma Yuyi You Kanishka Pushpitha Kunal Dhiman Mehdi Mirzaei Stuart Graham Vivek Gupta Source Type: research

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