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Management: National Institutes of Health (NIH)
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Total 11251 results found since Jan 2013.
Rigor, Reproducibility, and Transparency in Shared Research Resources: Follow-Up Survey and Recommendations for Improvements
J Biomol Tech. 2022 Aug 16;33(3):3fc1f5fe.fa789303. doi: 10.7171/3fc1f5fe.fa789303. eCollection 2022 Oct 15.ABSTRACTRigor, reproducibility, and transparency (RR&T) are essential components of all scientific pursuits. Shared research resources, also known as core facilities, are on the frontlines of ensuring robust RR&T practices. The Association of Biomolecular Resource Facilities Committee on Core Rigor and Reproducibility conducted a follow-up survey 4 years after the initial 2017 survey to determine if core facilities have seen a positive impact of new RR&T initiatives (including guidance from the National I...
Source: Journal of Biomolecular Techniques : JBT - March 13, 2023 Category: Molecular Biology Authors: Andrew W Ott Katia Sol-Church Gauravi M Deshpande Kevin L Knudtson Susan M Meyn Sheenah M Mische Douglas J Taatjes Michael R Sturges Christopher W Gregory Source Type: research
Identification of significant gene expression changes in multiple perturbation experiments using knockoffs
Brief Bioinform. 2023 Mar 9:bbad084. doi: 10.1093/bib/bbad084. Online ahead of print.ABSTRACTLarge-scale multiple perturbation experiments have the potential to reveal a more detailed understanding of the molecular pathways that respond to genetic and environmental changes. A key question in these studies is which gene expression changes are important for the response to the perturbation. This problem is challenging because (i) the functional form of the nonlinear relationship between gene expression and the perturbation is unknown and (ii) identification of the most important genes is a high-dimensional variable selection...
Source: Briefings in Bioinformatics - March 9, 2023 Category: Bioinformatics Authors: Tingting Zhao Guangyu Zhu Harsh Vardhan Dubey Patrick Flaherty Source Type: research
The association of dietary and nutrient patterns on neurocognitive decline: a systematic review of MRI and PET studies
Ageing Res Rev. 2023 Mar 4:101892. doi: 10.1016/j.arr.2023.101892. Online ahead of print.ABSTRACTBACKGROUND: As the global population ages, there has been a growing incidence of neurodegenerative diseases such as Alzheimer's. More recently, studies exploring the relationship between dietary patterns and neuroimaging outcomes have received particular attention. This systematic literature review provides a structured overview of the association between dietary and nutrient patterns on neuroimaging outcomes and cognitive markers in middle-aged to older adults. A comprehensive literature search was conducted to find relevant a...
Source: Ageing Research Reviews - March 6, 2023 Category: Genetics & Stem Cells Authors: Lizanne Arnoldy Sarah Gauci Lauren M Young Wolfgang Marx Helen Macpherson Andrew Pipingas Oren Civier David J White Source Type: research
