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Source: Experimental and Therapeutic Medicine
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Total 541 results found since Jan 2013.
Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial-mesenchymal transition
Exp Ther Med. 2022 Jul 5;24(3):561. doi: 10.3892/etm.2022.11498. eCollection 2022 Sep.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a primary pathological subtype of RCC and has poor clinical outcome. Krüppel-like factors (KLFs), which are zinc-finger proteins, may be involved in ccRCC development and progression. KLFs belong to the zinc-finger family of DNA-binding transcription factors and regulate transcription of downstream target genes. KLFs are involved in cancer development. The present study aimed to investigate the role of KLFs in ccRCC prognosis. The Cancer Genome Atlas database and multifactorial analysis ...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: Fangfang Hu Yan Ren Zunyun Wang Hui Zhou Yumei Luo Minghua Wang Faqing Tian Jian Zheng Juan Du Gang Pang Source Type: research
Preventive measures significantly reduced the risk of nosocomial infection in elderly inpatients during the COVID-19 pandemic
Exp Ther Med. 2022 Jul 6;24(3):562. doi: 10.3892/etm.2022.11499. eCollection 2022 Sep.ABSTRACTIn December 2019, there was an outbreak of pneumonia of unknown causes in Wuhan, China. The etiological pathogen was identified to be a novel coronavirus, named severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). The number of infected patients has markedly increased since the 2019 outbreak and COVID-19 has also proven to be highly contagious. In particular, the elderly are among the group of patients who are the most susceptible to succumbing to COVID-19 within the ...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: Shuangshuang Wu Wen Liu Mingjiong Zhang Kai Wang Jin Liu Yujia Hu Quan She Min Li Shaoran Shen Bo Chen Jianqing Wu Source Type: research
Mutation analysis of circulating tumor DNA and paired ascites and tumor tissues in ovarian cancer
Exp Ther Med. 2022 Jun 30;24(3):542. doi: 10.3892/etm.2022.11479. eCollection 2022 Sep.ABSTRACTCirculating tumor DNA (ctDNA) is one conventional type of liquid biopsy that can be collected to dynamically monitor disease status. However, its potential clinical value and concordance with ascites samples or tumor biopsy needs to be evaluated further for patients with ovarian cancer. Therefore, the present study compared the mutation profiles among ctDNA, paired tumor tissue and ascites samples to explore their possible clinical value in ovarian cancer. Targeted next-generation sequencing was used to screen for mutations in 18...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: Xiaoxiang Jie Ming Du Meng Zhang Xiayu Jin Qingqing Cai Congjian Xu Xiaoyan Zhang Source Type: research
Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial-mesenchymal transition
Exp Ther Med. 2022 Jul 5;24(3):561. doi: 10.3892/etm.2022.11498. eCollection 2022 Sep.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a primary pathological subtype of RCC and has poor clinical outcome. Krüppel-like factors (KLFs), which are zinc-finger proteins, may be involved in ccRCC development and progression. KLFs belong to the zinc-finger family of DNA-binding transcription factors and regulate transcription of downstream target genes. KLFs are involved in cancer development. The present study aimed to investigate the role of KLFs in ccRCC prognosis. The Cancer Genome Atlas database and multifactorial analysis ...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: Fangfang Hu Yan Ren Zunyun Wang Hui Zhou Yumei Luo Minghua Wang Faqing Tian Jian Zheng Juan Du Gang Pang Source Type: research
Preventive measures significantly reduced the risk of nosocomial infection in elderly inpatients during the COVID-19 pandemic
Exp Ther Med. 2022 Jul 6;24(3):562. doi: 10.3892/etm.2022.11499. eCollection 2022 Sep.ABSTRACTIn December 2019, there was an outbreak of pneumonia of unknown causes in Wuhan, China. The etiological pathogen was identified to be a novel coronavirus, named severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). The number of infected patients has markedly increased since the 2019 outbreak and COVID-19 has also proven to be highly contagious. In particular, the elderly are among the group of patients who are the most susceptible to succumbing to COVID-19 within the ...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: Shuangshuang Wu Wen Liu Mingjiong Zhang Kai Wang Jin Liu Yujia Hu Quan She Min Li Shaoran Shen Bo Chen Jianqing Wu Source Type: research
Radial head arthroplasty vs. open reduction and internal fixation for the treatment of terrible triad injury of the elbow: A systematic review and meta-analysis update
Exp Ther Med. 2022 Jul 27;24(3):592. doi: 10.3892/etm.2022.11529. eCollection 2022 Sep.ABSTRACTTerrible triad injury of the elbow (TTIE) is a severe high-energy injury to the elbow, mainly including elbow dislocation, coronoid fracture and radial head fracture. It is difficult to maintain the stability of the elbow joint using traditional conservative treatment, and there is a high risk of redislocation and various complications. Therefore, surgical treatment is currently advocated, mainly for repairing damaged ligaments and reconstructing bony structures, but there is still controversy about the treatment plan for the rad...
Source: Experimental and Therapeutic Medicine - August 11, 2022 Category: General Medicine Authors: Xi-Yong Li Yun-Lu Wang Su Yang Peng-Fei Han Source Type: research
Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma
Exp Ther Med. 2022 Jun 16;24(2):521. doi: 10.3892/etm.2022.11449. eCollection 2022 Aug.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence is increasing and it is now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression and Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, the underlying mechanisms have remained to be clarified. Therefore, the main aim of the present study was to screen and investigate the key genes in regulating ferroptosis of the human hypoph...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Wei Mao Jian Ding Yu Li Ruofei Huang Baoxin Wang Source Type: research
Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)
Exp Ther Med. 2022 Jun 24;24(2):536. doi: 10.3892/etm.2022.11463. eCollection 2022 Aug.ABSTRACTAdsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, ...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Laura Gnesotto Guido Mioso Mauro Alaibac Source Type: research
Clinical features and management of 20 patients with hepatic portal venous gas
Exp Ther Med. 2022 Jun 17;24(2):525. doi: 10.3892/etm.2022.11452. eCollection 2022 Aug.ABSTRACTThe present study investigated the characteristics, diagnosis, treatment and prognosis of hepatic portal venous gas (HPVG) using the data of 20 patients from the Tongji University School of Medicine Affiliated with Yangpu Hospital (Shanghai, China). The aim of the present study was to optimize the management method and improve the prognosis of patients with HPVG. A total of 20 patients were selected using a CT scan to confirm HPVG. All patients were enrolled and identified via a search engine, which examined all CT radiology repo...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Yuan Zhang Hai-Long Liu Min Tang Hui Wang Hui-Hong Jiang Mou-Bin Lin Source Type: research
Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma
Exp Ther Med. 2022 Jun 16;24(2):521. doi: 10.3892/etm.2022.11449. eCollection 2022 Aug.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence is increasing and it is now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression and Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, the underlying mechanisms have remained to be clarified. Therefore, the main aim of the present study was to screen and investigate the key genes in regulating ferroptosis of the human hypoph...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Wei Mao Jian Ding Yu Li Ruofei Huang Baoxin Wang Source Type: research
Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)
Exp Ther Med. 2022 Jun 24;24(2):536. doi: 10.3892/etm.2022.11463. eCollection 2022 Aug.ABSTRACTAdsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, ...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Laura Gnesotto Guido Mioso Mauro Alaibac Source Type: research
Clinical features and management of 20 patients with hepatic portal venous gas
Exp Ther Med. 2022 Jun 17;24(2):525. doi: 10.3892/etm.2022.11452. eCollection 2022 Aug.ABSTRACTThe present study investigated the characteristics, diagnosis, treatment and prognosis of hepatic portal venous gas (HPVG) using the data of 20 patients from the Tongji University School of Medicine Affiliated with Yangpu Hospital (Shanghai, China). The aim of the present study was to optimize the management method and improve the prognosis of patients with HPVG. A total of 20 patients were selected using a CT scan to confirm HPVG. All patients were enrolled and identified via a search engine, which examined all CT radiology repo...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Yuan Zhang Hai-Long Liu Min Tang Hui Wang Hui-Hong Jiang Mou-Bin Lin Source Type: research
