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Source: Experimental and Therapeutic Medicine
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Total 541 results found since Jan 2013.
COVID-19: Main findings after a year and half of unease and the proper scientific progress (Review)
Exp Ther Med. 2022 Jun;23(6):424. doi: 10.3892/etm.2022.11350. Epub 2022 May 4.ABSTRACTSince the emergence of the disease in late December 2019, numerous studies have been published to date regarding clinical, laboratory and treatment aspects associated with COVID-19. The present study attempts to compare and unify the clinical, para-clinical and therapeutic aspects that have come to light regarding coronavirus disease-19 (COVID 19), mainly in adults. Between April 2020 and September 2021, a comprehensive systematic literature review was performed, which we added to from our own medical experiences. The search was performe...
Source: Experimental and Therapeutic Medicine - May 23, 2022 Category: General Medicine Authors: Marius Traian Leretter Dan Dumitru Vulcanescu Florin George Horhat Anamaria Matichescu Mircea Rivis Laura-Cristina Rusu Alexandra Roi Robert Racea Ioana Badea Cristina Adriana Dehelean Alexandra Mocanu Delia Ioana Horhat Source Type: research
mTORC1 is a key regulator that mediates OGD- and TGF β1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts
Exp Ther Med. 2022 Jun;23(6):413. doi: 10.3892/etm.2022.11340. Epub 2022 Apr 27.ABSTRACTIschemia-reperfusion infarct-derived chondroitin sulfate proteoglycans (CSPGs) are important for sustaining denervation of the infarct. Sympathetic denervation within the heart after myocardial infarction (MI) predicts the probability of a higher risk for serious ventricular arrhythmias. Chondroitin-4-sulfate (C4S) is the predominant chondroitin sulfate component in the heart. However, the mechanisms that induce CSPG expression in fibroblasts following MI remain to be elucidated. The present study found that oxygen-glucose deprivation (...
Source: Experimental and Therapeutic Medicine - May 23, 2022 Category: General Medicine Authors: Chao Li Zheng Zhang Yu Peng Yanying Zhang Wanrong Kang Yingdong Li Yang Hai Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Artificial intelligence applications and robotic systems in Parkinson's disease (Review)
Exp Ther Med. 2022 Feb;23(2):153. doi: 10.3892/etm.2021.11076. Epub 2021 Dec 17.ABSTRACTParkinson's disease (PD) is the second most frequent neurodegenerative disorder following Alzheimer's disease. Advanced stages of PD, 4 or 5 of the Hoehn and Yahr Scale, are characterized by severe motor complications, limited mobility without assistance, risk of falling, and non-motor complications. The aim of this review was to provide a practical overview on specific artificial intelligence (AI) systems for the management of advanced stages of PD, as well as relevant technological limitations. The authors conducted a systematic searc...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Lacramioara Perju-Dumbrava Maria Barsan Daniel Corneliu Leucuta Luminita C Popa Cristina Pop Nicoleta Tohanean Stefan L Popa Source Type: research
Congenitally missing second permanent molars in non-syndromic patients (Review)
Exp Ther Med. 2022 Feb;23(2):145. doi: 10.3892/etm.2021.11068. Epub 2021 Dec 15.ABSTRACTHypodontia (tooth agenesis) is regarded as the most common congenital dental anomaly. The present review discusses the epidemiological characteristics of congenitally missing second permanent molars (CMSPMs) within a systematic review of the literature. The review was based on Pubmed library associated with the search of various scientific databases or academic resources, improved by hand search of reference lists. The terms 'hypodontia' or 'anodontia' in combination with 'prevalence' or 'epidemiology' were searched in the data sources ...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Alexandru-Titus Farca șiu Rodica Luca Andreea Didilescu Ioana-Andreea Stanciu Catalina Farcasiu Arina Vinereanu Aneta Munteanu Source Type: research
Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Artificial intelligence applications and robotic systems in Parkinson's disease (Review)
Exp Ther Med. 2022 Feb;23(2):153. doi: 10.3892/etm.2021.11076. Epub 2021 Dec 17.ABSTRACTParkinson's disease (PD) is the second most frequent neurodegenerative disorder following Alzheimer's disease. Advanced stages of PD, 4 or 5 of the Hoehn and Yahr Scale, are characterized by severe motor complications, limited mobility without assistance, risk of falling, and non-motor complications. The aim of this review was to provide a practical overview on specific artificial intelligence (AI) systems for the management of advanced stages of PD, as well as relevant technological limitations. The authors conducted a systematic searc...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Lacramioara Perju-Dumbrava Maria Barsan Daniel Corneliu Leucuta Luminita C Popa Cristina Pop Nicoleta Tohanean Stefan L Popa Source Type: research
Congenitally missing second permanent molars in non-syndromic patients (Review)
Exp Ther Med. 2022 Feb;23(2):145. doi: 10.3892/etm.2021.11068. Epub 2021 Dec 15.ABSTRACTHypodontia (tooth agenesis) is regarded as the most common congenital dental anomaly. The present review discusses the epidemiological characteristics of congenitally missing second permanent molars (CMSPMs) within a systematic review of the literature. The review was based on Pubmed library associated with the search of various scientific databases or academic resources, improved by hand search of reference lists. The terms 'hypodontia' or 'anodontia' in combination with 'prevalence' or 'epidemiology' were searched in the data sources ...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Alexandru-Titus Farca șiu Rodica Luca Andreea Didilescu Ioana-Andreea Stanciu Catalina Farcasiu Arina Vinereanu Aneta Munteanu Source Type: research
Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
