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Source: Experimental and Therapeutic Medicine
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Total 541 results found since Jan 2013.
Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma
Exp Ther Med. 2022 Jun 16;24(2):521. doi: 10.3892/etm.2022.11449. eCollection 2022 Aug.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence is increasing and it is now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression and Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, the underlying mechanisms have remained to be clarified. Therefore, the main aim of the present study was to screen and investigate the key genes in regulating ferroptosis of the human hypoph...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Wei Mao Jian Ding Yu Li Ruofei Huang Baoxin Wang Source Type: research
Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)
Exp Ther Med. 2022 Jun 24;24(2):536. doi: 10.3892/etm.2022.11463. eCollection 2022 Aug.ABSTRACTAdsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, ...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Laura Gnesotto Guido Mioso Mauro Alaibac Source Type: research
Clinical features and management of 20 patients with hepatic portal venous gas
Exp Ther Med. 2022 Jun 17;24(2):525. doi: 10.3892/etm.2022.11452. eCollection 2022 Aug.ABSTRACTThe present study investigated the characteristics, diagnosis, treatment and prognosis of hepatic portal venous gas (HPVG) using the data of 20 patients from the Tongji University School of Medicine Affiliated with Yangpu Hospital (Shanghai, China). The aim of the present study was to optimize the management method and improve the prognosis of patients with HPVG. A total of 20 patients were selected using a CT scan to confirm HPVG. All patients were enrolled and identified via a search engine, which examined all CT radiology repo...
Source: Experimental and Therapeutic Medicine - July 15, 2022 Category: General Medicine Authors: Yuan Zhang Hai-Long Liu Min Tang Hui Wang Hui-Hong Jiang Mou-Bin Lin Source Type: research
GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway
In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.PMID:35761807 | PMC:PMC9214606 | DOI:10.3892/etm.2022.11400
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Liang Yao Fuguo Tian Source Type: research
The X box binding protein 1/C/EBP homologous protein pathway induces apoptosis of endothelial cells under hyperglycemia
Exp Ther Med. 2022 May 18;24(1):454. doi: 10.3892/etm.2022.11381. eCollection 2022 Jul.ABSTRACTVenous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X-box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelia...
Source: Experimental and Therapeutic Medicine - June 20, 2022 Category: General Medicine Authors: Maoshun Tang Yi Zheng Jianping Li Yuanlang Hu Source Type: research
