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Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may con...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Corrigendum: Correction of the Figure. Trends of stratified prostate cancer risk in a single Korean province from 2003 to 2021: A multicenter study conducted using regional training hospital data
Investig Clin Urol. 2023 Sep;64(5):514-516. doi: 10.4111/icu.20220317c.ABSTRACTThis corrects the article on p. 140 in vol. 64, PMID: 36882172.PMID:37668210 | DOI:10.4111/icu.20220317c
Source: Clinical Prostate Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Young Hwii Ko Byung Hoon Kim Se Yun Kwon Hyun Jin Jung Yoon Soo Hah Yeon-Joo Kim Hyun Tae Kim Jun Nyung Lee Jeong Hyun Kim Tae-Hwan Kim Daegu-Kyungbook Urologic Oncology Study Group Source Type: research
A prospective, multicenter study on the clinical effectiveness of abiraterone in metastatic castration-resistant prostate cancer in Korea: Pre- vs. post-chemotherapy
CONCLUSIONS: In this postmarketing surveillance, AAP benefited patients with mCRPC, especially in settings before chemotherapy was administered, resulting in a high PSA response and longer PSA and radiologic progression-free survival with tolerable adverse drug reactions.PMID:37668202 | DOI:10.4111/icu.20230128
Source: Clinical Prostate Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Seung-Hwan Jeong Sang Eun Yeon Su Youn Kim Tae Gyun Kwon Seong Soo Jeon Young Deuk Choi Dongdeuk Kwon Byung Ha Chung Sung-Hoo Hong Byung Hoon Kim Hyo Jin Lee Sang Joon Shin Woo Suk Choi Sung Woo Park Taek Won Kang Seok Joong Yun Jin Seon Cho See Min Choi Source Type: research
Prostate-specific antigen screening for prostate cancer: An old but never-ending story
Investig Clin Urol. 2023 Sep;64(5):422-424. doi: 10.4111/icu.20230229.NO ABSTRACTPMID:37668197 | DOI:10.4111/icu.20230229
Source: Clinical Prostate Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Sun Il Kim Source Type: research
Poly (ADP-ribose) polymerase inhibitor: A new horizon in advanced prostate cancer treatment
Investig Clin Urol. 2023 Sep;64(5):419-421. doi: 10.4111/icu.20230185.NO ABSTRACTPMID:37668196 | DOI:10.4111/icu.20230185
Source: Clinical Prostate Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Minyong Kang Seong Soo Jeon Source Type: research
Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
CONCLUSION: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.PMID:37667572 | DOI:10.22037/uj.v20i.7469
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Zhu Wang Ying Zhang Qiong Deng Jianwen Zhang Xisheng Wang Hui Liang Source Type: research
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3;94:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may ...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
CONCLUSION: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.PMID:37667572 | DOI:10.22037/uj.v20i.7469
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Zhu Wang Ying Zhang Qiong Deng Jianwen Zhang Xisheng Wang Hui Liang Source Type: research
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may con...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
CONCLUSION: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.PMID:37667572 | DOI:10.22037/uj.v20i.7469
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Zhu Wang Ying Zhang Qiong Deng Jianwen Zhang Xisheng Wang Hui Liang Source Type: research
