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Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Publication date: Available online 6 April 2018Source: Molecular and Cellular EndocrinologyAuthor(s): L. Shcherbina, A. Lindqvist, A.-H. Thorén Fischer, E. Ahlqvist, E. Zhang, S.E. Falkmer, E. Renström, J. Koffert, H. Honka, N. WierupAbstractImpaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression.CART expression was foun...
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus
Glucagon-like peptide-1 (GLP-1) is a gut L-cell hormone that enhances glucose-stimulated insulin secretion. Several approaches that prevent GLP-1 degradation or activate the GLP-1 receptor are being used to treat type 2 diabetes mellitus (T2DM) patients. In T2DM, GLP-1 secretion has been suggested to be impaired, and this defect appears to be a consequence rather than a cause of impaired glucose homeostasis. However, although defective GLP-1 secretion has been correlated with insulin resistance, little is known about the direct effects of chronic high glucose concentrations, which are typical in diabetes patients, on GLP-1...
Source: AJP: Cell Physiology - March 31, 2016 Category: Cytology Authors: Urbano, F., Filippello, A., Di Pino, A., Barbagallo, D., Di Mauro, S., Pappalardo, A., Rabuazzo, A. M., Purrello, M., Purrello, F., Piro, S. Tags: Cell Signaling: Proteins, Pathways and Mechanisms CALL FOR PAPERS Source Type: research

Altered Expression of Uncoupling Protein 2 in GLP-1-producing Cells after Chronic High Glucose Exposure: Implications for the Pathogenesis of Diabetes Mellitus.
Abstract Glucagon-like peptide-1 (GLP-1) is a gut L-cell hormone that enhances glucose-stimulated insulin secretion. Several approaches that prevent GLP-1 degradation or activate the GLP-1 receptor are being used to treat type 2 diabetes mellitus (T2DM) patients. In T2DM, GLP-1 secretion has been suggested to be impaired, and this defect appears to be a consequence rather than a cause of impaired glucose homeostasis. However, although defective GLP-1 secretion has been correlated with insulin resistance, little is known about the direct effects of chronic high glucose concentrations, which are typical in diabetes ...
Source: American Journal of Physiology. Cell Physiology - January 6, 2016 Category: Cytology Authors: Urbano F, Filippello A, Di Pino A, Barbagallo D, Di Mauro S, Pappalardo A, Rabuazzo AM, Purrello M, Purrello F, Piro S Tags: Am J Physiol Cell Physiol Source Type: research