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Total 33 results found since Jan 2013.

Differential regulation of interleukin-8 and human beta-defensin 2 in Pseudomonas aeruginosa -infected intestinal epithelial cells
Conclusions: The P. aeruginosa-induced antimicrobial peptide in IECs continuously protect the host against prolonged infection, while modulation of proinflammatory responses prevents the host from the detrimental effects of overwhelming inflammation. Thus, P. aeruginosa-induced innate immunity in IECs represents a host protective mechanism, which may provide new insight into the pathogenesis of inflammatory bowel diseases.
Source: BMC Microbiology - November 30, 2014 Category: Microbiology Authors: Fu-Chen Huang Source Type: research

Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Mycobacterium tuberculosis primarily infects lung macrophages. However, a recent study showed that M. tuberculosis also infects and persists in a dormant form inside bone marrow mesenchymal stem cells (BM-MSCs) even after successful antibiotic therapy. However, the mechanism(s) by which M. tuberculosis survives in BM-MSCs is still not known. Like macrophages, BM-MSCs do not contain a well-defined endocytic pathway, which is known to play a central role in the clearance of internalized mycobacteria. Here, we studied the fate of virulent and avirulent mycobacteria in Sca-1+ CD44+ BM-MSCs. We found that BM-MSCs were able to k...
Source: Infection and Immunity - September 20, 2017 Category: Infectious Diseases Authors: Naik, S. K., Padhi, A., Ganguli, G., Sengupta, S., Pati, S., Das, D., Sonawane, A. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research

Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF- κB signaling in a cellular pneumonia model
CONCLUSIONS: These results provided promising management in preventing pneumonia in patients.PMID:35527663 | DOI:10.15586/aei.v50i3.581
Source: Allergologia et Immunopathologia - May 9, 2022 Category: Allergy & Immunology Authors: Adilijiang Kari Zhihua M Zhayidan Aili Ayinuerguli Adili Nadire Hairula Abulaiti Abuduhaer Source Type: research