Filtered By:
Source: Current Gene Therapy
Therapy: Gene Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 34 results found since Jan 2013.
Suppression of mTOR expression by siRNA leads to cell cycle arrest and apoptosis induction in MDA-MB-231 breast cancer cells
CONCLUSION: With these results, we can conclude that mTOR-siRNA exerts direct 'anti-breast cancer' activity propagated by the S6K-GSK-3β- caspase 3 mediated apoptosis and by inducing cell cycle arrest.PMID:36999418 | DOI:10.2174/1566523223666230329085606
Source: Current Gene Therapy - March 31, 2023 Category: Genetics & Stem Cells Authors: Roja Sahu Shivesh Jha Shakti Pattanayak Source Type: research
Gene therapy in the anterior eye segment
Curr Gene Ther. 2021 Apr 22. doi: 10.2174/1566523221666210423084233. Online ahead of print.ABSTRACTThis review provides comprehensive information about the advances in gene therapy in the anterior segment of the eye including cornea, conjunctiva, lacrimal gland, and trabecular meshwork. We discuss gene delivery systems including viral and non-viral vectors as well as gene editing techniques, mainly CRISPR-Cas9, and epigenetic treatments including antisense and siRNA therapeutics. We also provide a detailed analysis of various anterior segment diseases where gene therapy has been tested with corresponding outcomes. Disease ...
Source: Current Gene Therapy - April 27, 2021 Category: Genetics & Stem Cells Authors: Cynthia Amador Ruchi Shah Sean Ghiam Andrei A Kramerov Alexander V Ljubimov Source Type: research
