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Monocarboxylate Transporter ‐1 Mediates the Protective Effects of Neutral‐pH Bicarbonate/Lactate‐Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis
Abstract We investigated the effects of bicarbonate/lactate‐buffered peritoneal dialysis fluid (B/L‐PDF) and lactate‐buffered PDF (L‐PDF) on cell viability and apoptosis, focusing on monocarboxylate transporters (MCTs). MCT‐1 transports lactate into cells. Cell viability and apoptosis of human peritoneal mesothelial cells (HPMCs) were examined by water‐soluble tetrazolium salt‐1 and TUNEL assays, respectively. The relative number of viable HPMCs was significantly decreased by L‐PDF at 48 h (8.8 ± 0.4%) compared with cells cultured in M199, but not by B/L‐PDF (66.7 ± 1.1%). Apoptosis was marked...
Source: Therapeutic Apheresis and Dialysis - December 11, 2016 Category: Hematology Authors: Akihiro Kuma, Masahito Tamura, Nana Ishimatsu, Yoshikazu Harada, Hiroto Izumi, Tetsu Miyamoto, Yumi Furuno, Yoko Nakano, Ryota Serino, Yutaka Otsuji Tags: Original Article Source Type: research