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Haemonchus contortus: siRNA mediated knockdown of matrix metalloproteinase 12A (MMP-12) results in reduction of infectivity
RNA interference (RNAi) is an important tool to determine the role of genes. RNAi has been widely used to downregulate target molecules, resulting in the reduction of mRNA for protein expression. Matrix metall...
Source: Parasites and Vectors - March 24, 2020 Category: Microbiology Authors: Muhammad Ali-ul-Husnain Naqvi, Hao Li, Wenxiang Gao, Sana Zahra Naqvi, Tahseen Jamil, Kalibixiati Aimulajiang, Lixin Xu, Xiaokai Song, Xiangrui Li and Ruofeng Yan Tags: Research Source Type: research

Functional analysis of a novel parasitic nematode-specific protein of Setaria digitata larvae in Culex quinquefasciatus by siRNA mediated RNA interference
Functional analysis of animal parasitic nematode genes is often quite challenging due to the unavailability of standardised in vitro culture conditions and lack of adequate tools to manipulate these genes. Theref...
Source: Parasites and Vectors - October 10, 2018 Category: Microbiology Authors: Magalla Bastian Chalitha Lakmal Somarathne, Yasanthi Illika Nilmini Silva Gunawardene, Naduvilath Vishvanath Chandrasekharan, Arjuna Nisantha Bandara Ellepola and Ranil Samantha Dassanayake Tags: Research Source Type: research

Molecular insights into a tetraspanin in the hydatid tapeworm Echinococcus granulosus
Conclusions: This is the first report characterizing a tetraspanin from the tapeworm E. granulosus. Our results suggest that Eg-TSP1 is associated with biogenesis of the tegument and maintenance of structural integrity of E. granulosus and could therefore be a candidate intervention target for control of hydatid disease.
Source: Parasites and Vectors - June 10, 2015 Category: Microbiology Authors: Dandan HuXingju SongYue XieXiuqin ZhongNing WangYu ZhengXiaobin GuTao WangXuerong PengGuangyou Yang Source Type: research

Effect of the silencing of the Ehcp112 gene on the in vitro virulence of Entamoeba histolytica
This study described that the silencing of the cysteine proteinase EhCP112 in Entamoeba histolytica produces a significant reduction in cytolysis and phagocytosis, indicating the participation of this proteinase in the in vitro virulence of the parasite. Image: A) Internalization of a fluorescein-labeled siRNA. B) EhCP112 silencing.
Source: Parasites and Vectors - August 28, 2013 Category: Microbiology Authors: Ramón Ocádiz-RuizWendy FonsecaMáximo MartínezRamón Ocádiz-QuintanarEsther OrozcoMario Rodríguez Source Type: research