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Total 170 results found since Jan 2013.
CLEC4A and CLEC12B C-type lectin receptors mediate interactions with < em > Pneumocystis < /em > cell wall components
Conclusion. The data presented here provide new members of the CLRs family recognizing Pneumocystis. Future studies using CLEC4A and/or CLEC12B deficient mice in the PCP mouse model should provide further insights into the host immunological response to Pneumocystis.PMID:37294293 | DOI:10.1099/jmm.0.001714
Source: Journal of Medical Microbiology - June 9, 2023 Category: Microbiology Authors: Theodore J Kottom Eva M Carmona Kyle Schaefbauer Andrew H Limper Source Type: research
Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors
Corona Virus Disease 2019 (COVID-19) continues to be a burden for human health since its outbreak in Wuhan, China in December 2019. Recently, the emergence of new variants of concerns (VOCs) is challenging for vaccines and drugs efficiency. In severe cases, SARS-CoV-2 provokes inappropriate hyperinflammatory immune responses leading to acute respiratory distress syndrome (ARDS) and even death. This process is regulated by inflammasomes which are activated after binding of the viral spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2) receptor and triggers innate immune responses. Therefore, the formation of...
Source: Frontiers in cellular and infection microbiology - June 9, 2023 Category: Microbiology Source Type: research
Herpes simplex virus type I glycoprotein L evades host antiviral innate immunity by abrogating the nuclear translocation of phosphorylated NF- κB sub-unit p65
Nuclear factor (NF)-κB plays an important role in the innate immune response by inducing antiviral genes’ expression. However, the herpes simplex virus 1 (HSV-1) virus has developed multiple ways to interfere with NF-κB activity to escape the host antiviral response. Here, we found that HSV-1 envelope glycoprotein L(gL) markedly inhibits interferon (IFN) production and its downstream antiviral genes. Our results showed that ectopic expression of gL inhibited IFN-β promoter activation, and decreased IFN-β production, the expression of IFN-stimulated genes (ISGs), and inhibited immunologic stimulant (poly I:C) induced ...
Source: Frontiers in Microbiology - May 9, 2023 Category: Microbiology Source Type: research
The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication
ConclusionThese results suggest that the CyHV-2 proteins ORF23 and ORF141 function as viral ribonucleotide reductase and their function makes an effect to CyHV-2 replication. Targeting ribonucleotide reductase could be a crucial strategy for developing new antiviral drugs against CyHV-2 and other herpesviruses.
Source: Frontiers in Microbiology - April 18, 2023 Category: Microbiology Source Type: research
Prophylactic intranasal administration of lipid nanoparticle formulated siRNAs reduce SARS-CoV-2 and RSV lung infection
J Microbiol Immunol Infect. 2023 Mar 8:S1684-1182(23)00068-3. doi: 10.1016/j.jmii.2023.02.010. Online ahead of print.ABSTRACTRNA interference (RNAi) is an emerging and promising therapy for a wide range of respiratory viral infections. This highly specific suppression can be achieved by the introduction of short-interfering RNA (siRNA) into mammalian systems, resulting in the effective reduction of viral load. Unfortunately, this has been hindered by the lack of a good delivery system, especially via the intranasal (IN) route. Here, we have developed an IN siRNA encapsulated lipid nanoparticle (LNP) in vivo delivery system...
Source: Journal of Microbiology, Immunology, and Infection - March 18, 2023 Category: Microbiology Authors: Aroon Supramaniam Yaman Tayyar Daniel T W Clarke Gabrielle Kelly Dhruba Acharya Kevin V Morris Nigel A J McMillan Adi Idris Source Type: research
Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis
ConclusionOur findings indicate that the SNHG9/miR-150-5p/c-Fos axis influences EV-D68 replication in host cells and that SNHG9 may be a possible target for anti-EV-D68 infection therapies.
Source: Frontiers in Microbiology - January 19, 2023 Category: Microbiology Source Type: research
MiR-199a-3p-regulated alveolar macrophage-derived secretory autophagosomes exacerbate lipopolysaccharide-induced acute respiratory distress syndrome
ConclusionThe novel finding of this study is that MiR-199a-3p participated in the regulation of SAP secretion and the inflammatory process via targeting of PAK4/Rab8a, and is a potential therapeutic candidate for ARDS treatment.
Source: Frontiers in cellular and infection microbiology - November 29, 2022 Category: Microbiology Source Type: research
