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Moraxella catarrhalis induces CEACAM3‐Syk‐Card9‐dependent activation of human granulocytes
Summary The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes are present in the airways, which correlate with bacteria‐induced exacerbations and severity of the disease. Our study investigated whether the interaction of M. catarrhalis with the human granulocyte‐specific carcinoembryonic antigen‐related cell adhesion molecule (CEACAM)‐3 is linked to NF‐κB activation, resulting in chemokine production. Granulocytes from healthy donors and NB4 cells were infected wi...
Source: Cellular Microbiology - March 31, 2016 Category: Microbiology Authors: A Heinrich, KA Heyl, E Klaile, MM Müller, TE Klassert, A Wiessner, K Fischer, RR Schumann, U Seifert, K Riesbeck, A Moter, BB Singer, S Bachmann, H Slevogt Tags: Research article Source Type: research

Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment.
Abstract Chlamydia pneumoniae infections of the respiratory tract are common and are associated with acute and chronic diseases such as community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (COPD). Recent studies have shown that reduced environmental oxygen availability promotes chlamydial growth in infected host cells. The underlying mechanisms remain unclear. We performed a targeted siRNA screen coupled with an automated high-throughput microscopic analysis to identify key host cell genes that play a role in promoting the hypoxic growth of C. pneumoniae. A total of 294 siRNAs - targeting 9...
Source: International Journal of Medical Microbiology - April 6, 2013 Category: Microbiology Authors: Szaszák M, Shima K, Käding N, Hannus M, Solbach W, Rupp J Tags: Int J Med Microbiol Source Type: research