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Inability of DNAzymes to cleave RNA in vivo is due to limited MgFormula: see text concentration in cells.
Abstract Sequence specific cleavage of RNA can be achieved by hammerhead ribozymes as well as DNAzymes. They comprise a catalytic core sequence flanked by regions that form double strands with complementary RNA. While different types of ribozymes have been discovered in natural organisms, DNAzymes derive from in vitro selection. Both have been used for therapeutic down-regulation of harmful proteins by reducing drastically the corresponding mRNA concentration. A priori DNAzymes appear advantageous because of the higher haemolytic stability and better cost effectiveness when compared to RNA. In the present work the...
Source: European Biophysics Journal : EBJ - December 16, 2017 Category: Physics Authors: Victor J, Steger G, Riesner D Tags: Eur Biophys J Source Type: research