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MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF- α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway.
MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4110-4118 Authors: Zhang C, Ye B, Wei J, Wang Q, Xu C, Yu G Abstract Abnormally expressed miR-199a-5p (miR-199a) has been frequently reported in multiple types of malignancies. Nevertheless, its effect in liver regeneration (LR) is largely still unclear. Herein, we investigated the function of miR-199a in hepatocyte proliferation during LR. As a result, miR-199a expression was significantly increased 12-30 h, in ...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 5, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

PLCG2 promotes hepatocyte proliferation in vitro via NF- κB and ERK pathway by targeting bcl2, myc and ccnd1.
In this study, we investigate the mechanism of PLCG2 action using a short interference RNA (siRNA) method. The effects of PLCG2 on rat liver BRL-3A cells treated siRNA were studied by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT assay), bromodeoxyuridine (BrdU) labelling assay, flow cytometry method (FCM), quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. The results showed when PLCG2 was reduced, cell vitality and proliferation rate were significantly decreased (p < .05 vs. control). FCM analysis showed that the number of cell division phase (G2 + M) was decl...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 26, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Osteopontin promotes rat hepatocyte proliferation both in vitro and in vivo.
Conclusion: OPN promotes hepatocyte proliferation both in vitro and in vivo through STAT3 and AKT signaling pathways. PMID: 31544532 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - September 25, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Preparation and evaluation of a non-viral gene vector for SiRNA: Multifunctional envelope-type nano device.
Authors: Zhang Y, Wei H, Xu L, Yan G, Ma C, Yu M, Wei C, Sun Y Abstract We prepared and evaluated a multifunctional envelope-type nano device (MEND) as a liver-targeting and long-circulation carrier for SiRNA. The polymer GA-PEG-Pp-DOPE was synthesized by modifying polyethylene glycol (PEG) with glycyrrhetinic acid (GA), peptide (Pp), and dioleoyl phosphoethanolamine (DOPE). The Pp is a substrate of matrix metalloproteinase 2. MEND was prepared with GA-PEG-Pp-DOPE and cationic phospholipids by the filming-rehydration method, and the orthogonal test was applied to optimize the prescription. The results of the biolog...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 12, 2015 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research