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Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles
Colloids Surf B Biointerfaces. 2022 Sep 28;220:112880. doi: 10.1016/j.colsurfb.2022.112880. Online ahead of print.ABSTRACTThe present study aimed to determine the effects of sucrose on the physical stability, cellular entry pathways and functional efficacy of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs). PLGA-NPs were synthesized in the absence or presence of 10 % sucrose, using HEI-101, an unmodified small interfering RNA (siRNA), as a drug model. The newly synthesized HEI-101-loaded PLGA-NPs (HEI-101-NPs) were exposed to repeated freeze-thaw cycles and iteratively tested over a six-month evaluation period. The ...
Source: Colloids and Surfaces - October 14, 2022 Category: Biotechnology Authors: Ibrahima Youm Matthew B West Xiangping Huang Wei Li Richard D Kopke Source Type: research