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Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells
This study is the first report on co-delivery of MTX and STAT3 siRNA by chitosan modified MSNs.PMID:35132929 | DOI:10.1080/21691401.2022.2030746
Source: Artificial Cells, Nanomedicine and Biotechnology - February 8, 2022 Category: Biotechnology Authors: Zahra Shakeran Jaleh Varshosaz Mehrnaz Keyhanfar Hossein Mohammad-Beigi Karim Rahimi Duncan S Sutherland Source Type: research

Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21.
In conclusion, the neuroprotective effects of MEG3 silence on PC12 cells injured by hypoxia were observed in this study. Mechanistically, the neuroprotective effects of MEG3 silence on PC12 cells were via sponging miR-21 and thus regulating PI3K/AKT and NF-κB pathways.HIGHLIGHTSMEG3 is highly expressed in PC12 cells following hypoxic injury;Silence of MEG3 prevents hypoxia-induced cell damage in PC12 cells;MEG3 acts as a miR-21 sponge;MEG3 sponges miR-21 to regulate PI3K/AKT and NF-κB pathways. PMID: 32050796 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - February 14, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145.
Conclusion: The protective function of cZNF609 silence in H2O2-injured HaCaT cells was revealed in vitro. Silence of cZNF609 exhibited its impact possibly through regulating miR-145, and JNK and p38MAPK pathways. PMID: 31905030 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 8, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

miR-324-5p inhibits gallbladder carcinoma cell metastatic behaviours by downregulation of transforming growth factor beta 2 expression.
Authors: Zhang X, Zhang L, Chen M, Liu D Abstract Increasing studies have demonstrated that microRNAs (miRNAs) are associated with the metastasis of gallbladder carcinoma (GBC). Recently, miR-324-5p has been reported to be a tumour-suppressive miRNA in many types of malignant cancer. However, the biological function and molecular mechanism of miR-324-5p in GBC still remain largely unknown. Here, we found that miR-324-5p expression was notably down-regulated in both GBC tissues and cells compared with that in normal controls. Downregulated miR-324-5p expression was negatively associated with the status of local inva...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 22, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Fyn gene silencing reduces oligodendrocytes apoptosis through inhibiting ERK1/2 phosphorylation in epilepsy.
In conclusion, Fyn gene silencing reduced the apoptosis of OLs through inhibiting the phosphorylation of ERK1/2 in epileptic model. PMID: 31852295 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - December 21, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

EPO could be regulated by HIF-1 and promote osteogenesis and accelerate bone repair.
This study was aimed to clarify the effect of erythropoietin on the repair of bone defect. We added the designated concentration of rhEPO to endothelial progenitor cells and marrow stromal cells, then detected its osteogenic and angiogenesis effects. The results showed that rhEPO promoted the proliferation of EPC and ST2 by promoting the mitosis without affecting cell apoptosis. The protein and mRNA levels of angiogenesis and osteogenic related factors exhibited higher expressions. Additionally, rhEPO encapsulated in PLGA scaffolds accelerated the new bone formation in rat calvaria bone defect model. Since the centre of bo...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 19, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

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