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Proliferation-Related Features of the Human Mesenchymal Stem Cells Derived from Palatine Tonsils, Adipose Tissues, and Bone Marrow
Conclusion:Our study compared MSCs of different origins to better understand the similarities and differences among these cell types.
Source: Tissue Engineering and Regenerative Medicine - August 18, 2023 Category: Biotechnology Source Type: research

Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway under Hypoxia
Conclusion:In summary, herein, we present a novel mechanism of Hsp20-mediated regulation of canine EPCs via Akt activation in a hypoxic microenvironment.
Source: Tissue Engineering and Regenerative Medicine - August 30, 2022 Category: Biotechnology Source Type: research

Primary Cilia Mediate Wnt5a/ β-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction
Conclusion:Our data suggested that ciliogenesis was negatively regulated by Wnt5a/ β-catenin signaling during adipogenesis. Thus, we suggest that calcium induction triggers adipogenesis and ciliogenesis.
Source: Tissue Engineering and Regenerative Medicine - January 31, 2020 Category: Biotechnology Source Type: research

GM-CSF Enhances Mobilization of Bone Marrow Mesenchymal Stem Cells via a CXCR4-Medicated Mechanism
Conclusion:These results suggest that GM-CSF is a useful tool for mobilizing BM MSCs into the PB.
Source: Tissue Engineering and Regenerative Medicine - November 15, 2018 Category: Biotechnology Source Type: research

Local Silencing of Connective Tissue Growth Factor by siRNA/Peptide Improves Dermal Collagen Arrangements
Conclusion:CTGF expression was down-regulated to 40% of control by CTGF siRNA/KALA (1:24) complexes (p <  0.01) and collagen lattice contraction was inhibited. However, down-regulated of CTGF by CTGF siRNA/MPG∆NLS complexes was not statistically significant. CTGF KALA-treated wound appeared with well formed-basket weave pattern of collagen fibrils with mean diameter of 128  ± 22 nm (n = 821). Mismatch siRNA/KALA-treated wound showed a high frequency of parallel small diameter fibrils (mean 90 ± 20 nm, n = 563).Conclusion:Controlling over-expression of CTGF by peptide-mediated siRNA delivery cou...
Source: Tissue Engineering and Regenerative Medicine - November 14, 2018 Category: Biotechnology Source Type: research

Local Delivery of CTGF siRNA with Poly(sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing
This study exemplifies a successful treatment of cutaneous wound healing using a polymer system coupled with RNA interference. Hence, the approach holds a great promise for developing new treatments with novel targets in regenerative medicines.
Source: Tissue Engineering and Regenerative Medicine - May 12, 2017 Category: Biotechnology Source Type: research