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Specialty: Biotechnology
Source: Colloids and Surfaces
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Total 52 results found since Jan 2013.
The effect of novel tyrosine-modified polyethyleneimines on human albumin structure - Thermodynamic and spectroscopic study
Colloids Surf B Biointerfaces. 2023 May 16;227:113359. doi: 10.1016/j.colsurfb.2023.113359. Online ahead of print.ABSTRACTThe interaction of proteins with nanoparticle components are crucial for the evaluation of nanoparticle function, toxicity and biodistribution. Polyethyleneimines (PEIs) with defined tyrosine modifications are a class of novel polymers designed for improved siRNA delivery. Their interactions with biomacromolecules are still poorly described. This paper analyzes the interaction of different tyrosine-modified PEIs with human serum albumin as the most abundant serum protein. The ability of tyrosine modifie...
Source: Colloids and Surfaces - May 20, 2023 Category: Biotechnology Authors: Ma łgorzata Kubczak Marika Grodzicka Sylwia Michlewska Michael Karimov Alexander Ewe Achim Aigner Maria Bryszewska Maksim Ionov Source Type: research
Current advancements in self-assembling nanocarriers-based siRNA delivery for cancer therapy
Colloids Surf B Biointerfaces. 2022 Nov 2;221:113002. doi: 10.1016/j.colsurfb.2022.113002. Online ahead of print.ABSTRACTDifferent therapeutic practices for treating cancers have significantly evolved to compensate and/or overcome the failures in conventional methodologies. The demonstrated potentiality in completely inhibiting the tumors and in preventing cancer relapse has made nucleic acids therapy (NAT)/gene therapy as an attractive practice. This has been made possible because NAT-based cancer treatments are highly focused on the fundamental mechanisms - i.e., silencing the expression of oncogenic genes responsible fo...
Source: Colloids and Surfaces - November 12, 2022 Category: Biotechnology Authors: Ganeshlenin Kandasamy Dipak Maity Source Type: research
Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles
Colloids Surf B Biointerfaces. 2022 Sep 28;220:112880. doi: 10.1016/j.colsurfb.2022.112880. Online ahead of print.ABSTRACTThe present study aimed to determine the effects of sucrose on the physical stability, cellular entry pathways and functional efficacy of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs). PLGA-NPs were synthesized in the absence or presence of 10 % sucrose, using HEI-101, an unmodified small interfering RNA (siRNA), as a drug model. The newly synthesized HEI-101-loaded PLGA-NPs (HEI-101-NPs) were exposed to repeated freeze-thaw cycles and iteratively tested over a six-month evaluation period. The ...
Source: Colloids and Surfaces - October 14, 2022 Category: Biotechnology Authors: Ibrahima Youm Matthew B West Xiangping Huang Wei Li Richard D Kopke Source Type: research
Multifunctional magnetic nanocarriers for delivery of siRNA and shRNA plasmid to mammalian cells: Characterization, adsorption and release behaviors
This study introduces a new MNP functionalization that can be used for the magnetically driven intracellular delivery of nucleic acids.PMID:36162177 | DOI:10.1016/j.colsurfb.2022.112861
Source: Colloids and Surfaces - September 26, 2022 Category: Biotechnology Authors: Chi-Hsien Liu Cheng-Han Lin Yi-Jun Chen Wei-Chi Wu Chun-Chao Wang Source Type: research
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research
Polymeric nanoparticles-siRNA as an emerging nano-polyplexes against ovarian cancer
Colloids Surf B Biointerfaces. 2022 Aug 9;218:112766. doi: 10.1016/j.colsurfb.2022.112766. Online ahead of print.ABSTRACTOvarian cancer (OC) is considered fifth-deadliest cancer globally responsible for high mortality in women. As the conventional therapeutic and diagnostic approaches are ineffective in increasing the survival rates of advanced staged patients by more than 5 years, OC has resulted in high morbidity and mortality rates over the last two decades. As a result, there is a dire need for innovative treatment approaches to address the issues. RNAi and nanotechnology can be considered the most appropriate strategi...
Source: Colloids and Surfaces - August 22, 2022 Category: Biotechnology Authors: Urushi Rehman Neha Parveen Afsana Sheikh Mohammed A S Abourehab Amirhossein Sahebkar Prashant Kesharwani Source Type: research
Mesoporous silica nanoparticle-modified electrode arrays of cochlear implants for delivery of siRNA-TGF β1 into the inner ear
Colloids Surf B Biointerfaces. 2022 Aug 4;218:112753. doi: 10.1016/j.colsurfb.2022.112753. Online ahead of print.ABSTRACTCochlear implants (CI) are widely used in patients to restore hearing function. Uncontrolled fibrosis in the cochleae induced by excess secretion of TGFβ1 seriously affects the effectiveness of CIs. siRNA is a potential therapeutic strategy to downregulate TGFβ1 specifically. However, treatment with siRNA in cochleae is difficult due to the poor penetration capability and instability of siRNA and the inaccessibility and vulnerability of cochleae. To address these challenges, we developed amino-function...
Source: Colloids and Surfaces - August 13, 2022 Category: Biotechnology Authors: Anning Chen Yaoheng Chen Shixin Liu Dong Ma Jie Tang Hongzheng Zhang Source Type: research
