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A novel anti-inflammatory role links the CARS2 locus to protection from coronary artery disease
CONCLUSIONS: These data highlight a novel anti-inflammatory novel role for CARS2 in human macrophages and SMCs that may underlie the protective effect of a common GWAS-identified variant.PMID:35381443 | DOI:10.1016/j.atherosclerosis.2022.03.024
Source: Atherosclerosis - April 5, 2022 Category: Cardiology Authors: Anh-Thu Dang Adam W Turner Paulina Lau Dhanuddara Mohottalage Yuet Kay Stephanie Fong Per Eriksson Lasse Folkersen Ljubica Matic Ulf Hedin S ébastien Soubeyrand Ruth McPherson Source Type: research

The Human- and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
CONCLUSIONS: Collectively, we demonstrate that SMILR is a critical mediator of vascular smooth muscle cell proliferation via direct regulation of mitotic progression. Our data further reveals a potential SMILR-targeting intervention to limit atherogenesis and adverse vascular remodeling. PMID: 31339449 [PubMed - as supplied by publisher]
Source: Circulation Research - July 23, 2019 Category: Cardiology Authors: Mahmoud AD, Ballantyne MD, Miscianinov V, Pinel K, Hung J, Scanlon JP, Iyinikkel J, Kaczynski J, Tavares AA, Bradshaw AC, Mills NL, Newby DE, Caporali A, Gould GW, George S, Ulitsky I, Sluimer JC, Rodor J, Baker AH Tags: Circ Res Source Type: research