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Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
Cell Signal. 2022 Jul 26:110419. doi: 10.1016/j.cellsig.2022.110419. Online ahead of print.ABSTRACTIntraplaque hemorrhage (IPH) accelerates atherosclerosis progression. To scavenge excessive red blood cells (RBCs), vascular smooth muscle cells (VSMCs) with great plasticity may function as phagocytes. Here, we investigated the erythrophagocytosis function of VSMCs and possible regulations involved. Based on transcriptional microarray analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that genes up-regulated in human carotid atheroma with IPH were enriched in functions of phagocytic activiti...
Source: Atherosclerosis - July 29, 2022 Category: Cardiology Authors: Daorong Pan Wen Wu Guangfeng Zuo Xiangrong Xie Hui Li Xiaomin Ren Chaohua Kong Wenying Zhou Zihan Zhang Martin Waterfall Shaoliang Chen Source Type: research

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900
Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research