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Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
CONCLUSIONS: The miRNA transcriptomic signature of circulating sEVs uncovered their pathologic role, devoid of the calcification-protective miRNAs that target VEGFA signaling in CKD-driven vascular calcification. These sEV-propagated miRNAs are potential biomarkers and therapeutic targets for vascular calcification.PMID:36700539 | DOI:10.1161/CIRCRESAHA.122.321939
Source: Circulation Research - January 26, 2023 Category: Cardiology Authors: Takaaki Koide Shintaro Mandai Reo Kitaoka Hisazumi Matsuki Motoko Chiga Kouhei Yamamoto Kotaro Yoshioka Yohsuke Yagi Soichiro Suzuki Tamami Fujiki Fumiaki Ando Takayasu Mori Koichiro Susa Soichiro Iimori Shotaro Naito Eisei Sohara Tatemitsu Rai Takanori Y Source Type: research

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research

GSK-3 β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
CONCLUSIONS: We identified a novel mechanism by which GSK-3β localizes to the myofilament to modulate LDA. Importantly, z-disc GSK-3β levels were reduced in patients with heart failure, indicating z-disc localized GSK-3β is a possible therapeutic target to restore the Frank-Starling mechanism in patients with heart failure.PMID:35168370 | DOI:10.1161/CIRCRESAHA.121.319491
Source: Circulation Research - February 16, 2022 Category: Cardiology Authors: Marisa J Stachowski-Doll Maria Papadaki Thomas G Martin Weikang Ma Henry M Gong Stephanie Shao Shi Shen Nitha Aima Muntu Mohit Kumar Edith Perez Jody L Martin Christine S Moravec Sakthivel Sadayappan Stuart G Campbell Thomas Irving Jonathan A Kirk Source Type: research

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900
Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research

Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension
Conclusions: We define a previously unrecognized interaction of human endothelial cells and monocytes that promote formation of AS DCs in hypertension and show a critical role of GAS6 and Axl signaling in both immune cells and endothelial cells. This pathway is potentially a novel therapeutic target to reduce inflammation and end organ damage in hypertension.PMID:34565181 | DOI:10.1161/CIRCRESAHA.121.319643
Source: Circulation Research - September 27, 2021 Category: Cardiology Authors: Justin Pieter Van Beusecum Natalia Ruggeri Barbaro Charles Duncan Smart David M Patrick Roxana Loperena Shilin Zhao Nestor de la Visitacion Mingfang Ao Liang Xiao Cyndya A Shibao David G Harrison Source Type: research

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