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Specialty: Biology
Source: Life Sciences
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Total 146 results found since Jan 2013.
hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin
Publication date: 15 July 2021Source: Life Sciences, Volume 277Author(s): Somayyeh Ghareghomi, Shahin Ahmadian, Nosratollah Zarghami, Salar Hemmati
Source: Life Sciences - May 17, 2021 Category: Biology Source Type: research
Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy
Publication date: Available online 28 March 2021Source: Life SciencesAuthor(s): Sepideh Mirzaei, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Kiavash Hushmandi, Vahid Rahmanian, Maliheh Entezari, Yarabahally R. Girish, Kothanahally S. Sharath Kumar, Amir Reza Aref, Pooyan Makvandi, Milad Ashrafizadeh, Ali Zarrabi, Haroon Khan
Source: Life Sciences - March 29, 2021 Category: Biology Source Type: research
Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems
Publication date: Available online 16 March 2021Source: Life SciencesAuthor(s): Sepideh Mirzaei, Mahmood Khaksary Mahabady, Amirhossein Zabolian, Alireza Abbaspour, Peyman Fallahzadeh, Maedeh Noori, Farid Hashemi, Kiavash Hushmandi, Salman Daneshi, Alan Prem Kumar, Amir Reza Aref, Saeed Samarghandian, Pooyan Makvandi, Haroon Khan, Michael R. Hamblin, Milad Ashrafizadeh, Ali Zarrabi
Source: Life Sciences - March 16, 2021 Category: Biology Source Type: research
Advances in siRNA delivery strategies for the treatment of MDR cancer
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Md Abdus Subhan, Sara Aly Attia, Vladimir P. Torchilin
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research
Co-delivery of EGFR and BRD4 siRNA by cell-penetrating peptides-modified redox-responsive complex in triple negative breast cancer cells
Publication date: Available online 10 December 2020Source: Life SciencesAuthor(s): Chi Zhang, Wen Yuan, Ying Wu, Xu Wan, Yanling Gong
Source: Life Sciences - December 13, 2020 Category: Biology Source Type: research
Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
Publication date: Available online 9 December 2020Source: Life SciencesAuthor(s): Shima Bastaki, Surendar Aravindhan, Nasrin Ahmadpour Saheb, Mahsa Afsari Kashani, Aleksi Evgenievich Dorofeev, Fariba Karoon Kiani, Hediyeh Jahandideh, Farzaneh Beigi Dargani, Mohsen Aksoun, Afshin Nikkhoo, Ali Masjedi, Ata Mahmoodpoor, Majid Ahmadi, Sanam Dolati, Simin Namvar, Farhad Jadidi-Niaragh
Source: Life Sciences - December 10, 2020 Category: Biology Source Type: research
Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression
Publication date: Available online 14 September 2020Source: Life SciencesAuthor(s): Sevda Salimifard, Fariba Karoon Kiani, Farzaneh Sadat Eshaghi, Sepideh Izadi, Kolsoom Shahdadnejad, Ali Masjedi, Morteza Heydari, Armin Ahmadi, Mohammad Hojjat-Farsangi, Hadi Hassannia, Hamed Mohammadi, Samaneh Boroumand-Noughabi, Mohammad Reza Keramati, Farhad Jadidi-Niaragh
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research
Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib
Publication date: 15 October 2020Source: Life Sciences, Volume 259Author(s): Shahin Hallaj, Sima Heydarzadeh Asl, Fatemeh Alian, Sajjad Farshid, Farzaneh Sadat Eshaghi, Afshin Namdar, Fatemeh Atyabi, Ali Masjedi, Tooba Hallaj, Anahita Ghorbani, Ghasem Ghalamfarsa, Mozhdeh Sojoodi, Farhad Jadidi-Niaragh
Source: Life Sciences - August 24, 2020 Category: Biology Source Type: research
Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway
This study aimed to determine the mechanism by which melatonin inhibits the proliferation of osteoblasts.Main methodsCell viability experiment, DNA fragment detection and alkaline phosphatase (ALP) activity assays were performed to determine the effects of melatonin on the proliferation, apoptosis and differentiation of osteoblasts. We used immunofluorescence to detect the expression of STIM1 in melatonin-treated osteoblasts. STIM1 interference was achieved using a specific siRNA, and a TRPC inhibitor was used to block the influx of Ca2+. The mRNA expression was determined by RT-qPCR, and protein levels were measured by We...
Source: Life Sciences - February 21, 2020 Category: Biology Source Type: research
Decreasing Arl4c expression by inhibition of AKT signal in human lung adenocarcinoma cells
ConclusionHere, we highlighted the AKT pathway as an important regulatory pathway for Arl4c expression in lung cancer cells and identified HCPT as a promising drug for lung adenocarcinoma treatment that functioned by targeting Arl4c expression.
Source: Life Sciences - February 13, 2020 Category: Biology Source Type: research
Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline
Publication date: Available online 8 February 2020Source: Life SciencesAuthor(s): Linlin Han, Nannan Song, Xiaomin Hu, Afang Zhu, Xin Wei, Jinmin Liu, Shiying Yuan, Weike Mao, Xiangdong ChenAbstractAimsAlthough resistin-like molecule β (RELM-β) is involved in the pathological processes of various lung diseases, such as pulmonary inflammation, asthma and fibrosis, its potential roles in hypoxic pulmonary arterial hypertension (PAH) remain largely unknown. The study aims to investigate whether RELM-β contributes to hypoxia-induced excessive proliferation of human pulmonary artery smooth muscle cells (PASMCs) and to explor...
Source: Life Sciences - February 9, 2020 Category: Biology Source Type: research
Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation
ConclusionsTaken together, this study suggests that STAT3/FoxO3a/p27Kip1 signaling pathway is involved in the anticancer effects of HCQ, and provides preliminary evidence for therapeutic prospects of HCQ alone in LUAD.Graphical abstract
Source: Life Sciences - January 29, 2020 Category: Biology Source Type: research
Small interfering RNA targeting alpha7 nicotinic acetylcholine receptor sensitizes hepatocellular carcinoma cells to sorafenib
Publication date: Available online 18 January 2020Source: Life SciencesAuthor(s): Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Behzad Mansoori, Vahid Khaze Shahgoli, Afshin Derakhshani, Ahad Mokhtarzadeh, Dariush Shanehbandi, Behzad BaradaranAbstractAimsIt has been demonstrated that reduced expression of alpha7 nicotinic acetylcholine receptor (α7nAChR) led to reduced chemotherapeutic drugs resistance in various cancer cells. However, whether small interfering RNA (siRNA) mediated knockdown of α7nAChR can reduce sorafenib (SOR) resistance in HCC cells remains to be determined.Materials and methodsThe effects of α7nACh...
Source: Life Sciences - January 18, 2020 Category: Biology Source Type: research
Syndecan-1 regulates extracellular matrix expression in keloid fibroblasts via TGF-β1/Smad and MAPK signaling pathways
Publication date: Available online 15 January 2020Source: Life SciencesAuthor(s): Jing Cui, Shan Jin, Chenglong Jin, Zhehu JinAbstractAimsThe present study aimed to explore the effect of syndecan-1 on keloid fibroblasts.Main methodsImmunohistochemistry and Western blot were employed to assess the expression of syndecan-1. Primary cultured keloid fibroblasts were transfected with syndecan-1 siRNA. The function of syndecan-1 on the proliferation of keloid fibroblasts was investigated through Cell Counting Kit-8 (CCK-8) and flow cytometry. Extracellular matrix, TGF-β1/Smad, and MAPK related proteins were evaluated by Western...
Source: Life Sciences - January 17, 2020 Category: Biology Source Type: research
Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway
This study aimed to investigate the characteristics and mechanism of autophagy on podocyte apoptosis under high glucose (HG) conditions and further explore the effect of berberine on podocyte autophagy, apoptosis and the potential mechanism.Materials and methodsThe levels of LC3II/I in podocytes stimulated with HG were detected at 0, 2, 4, 8, 12, 24, 36 and 48 h by western blotting. CCK-8 was used to detect the viability of podocytes. The level of autophagy was detected by western blotting, transmission electron microscopy and immunofluorescence. Podocyte apoptosis was analysed by using Hoechst staining, western blotting...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research
