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Drug: Methotrexate
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Total 1 results found since Jan 2013.
Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress
Free Radic Biol Med. 2021 Apr 6:S0891-5849(21)00195-7. doi: 10.1016/j.freeradbiomed.2021.03.035. Online ahead of print.ABSTRACTDioscin, one natural product, has various pharmacological actions. However, its effects on methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present study, the data manifested that dioscin restored the viabilities of L-02 and NRK-52E cells, reduced ALT, AST, Cr, BUN levels, and ameliorated histopathological changes of liver and kidney. Besides, dioscin decreased ROS levels in cells, and adjusted SOD, MDA, GSH and GSH-Px levels in rats. Dioscin reduced the expression levels...
Source: Free Radical Biology and Medicine - April 9, 2021 Category: Biology Authors: Y Li M Gao L-H Yin L-N Xu Y Qi Pengyuan Sun J-Y Peng Source Type: research
