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Therapy: Hormonal Therapy
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Estrogen receptor {beta}-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor {alpha} (TNF{alpha})-induced apoptosis Molecular Bases of Disease
Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying molecular mechanisms remain poorly understood. The inflammatory cytokine TNFα causes EC apoptosis while dysregulating the Notch pathway, a major contributor to EC survival. We have previously reported that 17β-estradiol (E2) treatment activates Notch signaling in ECs. Here, we sought to assess whether in TNFα-induced inflammation Notch is involved in E2-mediated protection...
Source: Journal of Biological Chemistry - November 3, 2017 Category: Chemistry Authors: Francesca Fortini, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Giorgio Aquila, Micaela Pannella, Antonio Pannuti, Lucio Miele, Roberto Ferrari, Paola Rizzo Tags: Cell Biology Source Type: research
