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Potential inhibitors and plant based technology: An alternative approach to treat corona virus
Bioorg Chem. 2021 Nov 1;117:105460. doi: 10.1016/j.bioorg.2021.105460. Online ahead of print.ABSTRACTThe current pneumonia outbreak, which began in early December 2019 near Wuhan City, Hubei Province, China, is caused by a novel corona virus (CoV) known as '2019-nCoV' or '2019 novel corona virus or COVID-19' by the World Health Organization (WHO). Vaccines are available to prevent corona virus contagious infection or to reduce the viral load in body but virus is continuously mutating itself to infect people at severity. In this critical scenario this review provide a compiled study for techniques and tools that can be used...
Source: Bioorganic Chemistry - November 11, 2021 Category: Chemistry Authors: Sachin Sharma Chetana Suvalka None Bharti Manoj Joshi Ayush Bahuguna Source Type: research

Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome Microbiology
Porcine deltacoronavirus (PDCoV) is a pathogen belonging to the genus Deltacoronavirus that in 2014 caused outbreaks of piglet diarrhea in the United States. To identify suitable therapeutic targets, a more comprehensive understanding of the viral entry pathway is required, particularly of the role of proteases. Here, we identified the proteases that activate the viral spike (S) glycoprotein to initiate cell entry and also pinpointed the host-cellular pathways that PDCoV uses for entry. Our results revealed that cathepsin L (CTSL) and cathepsin B (CTSB) in lysosomes and extracellular trypsin in cell cultures independently ...
Source: Journal of Biological Chemistry - June 20, 2019 Category: Chemistry Authors: Jialin Zhang, Jianfei Chen, Da Shi, Hongyan Shi, Xin Zhang, Jianbo Liu, Liyan Cao, Xiangdong Zhu, Ye Liu, Xiaobo Wang, Zhaoyang Ji, Li Feng Tags: Microbiology Source Type: research