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miR-4463 regulates aromatase expression and activity for 17 β-estradiol synthesis in response to follicle-stimulating hormone.
Conclusion: In this study, we identified differentially expressed miRNAs related to FSH responsiveness. In particular, upregulation of miR-4463 expression by FSHR deficiency in human granulosa cells impaired 17β-estradiol synthesis by targeting CYP19A1 and ESR1. Therefore, our data might provide novel candidates for molecular biomarkers for use in research into poor responders. PMID: 32854459 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Reproductive Medicine - August 30, 2020 Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research

Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells.
Conclusion: These results imply that sex hormones exerted a suppressive effect on the function of TLR3 in the fallopian tube cell line when different concentrations of sex hormones were present. The current results also suggest that estrogen receptor beta and nuclear progesterone receptor B are likely to mediate the hormonal regulation of TLR3, as these two receptors are the main estrogen and progesterone receptors in OE-E6/E7 cell line. PMID: 30538945 [PubMed]
Source: Clinical and Experimental Reproductive Medicine - December 13, 2018 Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research