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Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve
This study describes, for the first time, the existence of sub-populations of primordial follicles on the basis of K8/K18 expression in granulosa cells, and that their proportions change with age. While a progressive increase in K8/K18 expression cannot be ruled out, our data are consistent with the hypothesis that primordial follicles expressing low levels of K8/K18 are preferentially ablated by follicle attrition, while primordial follicles showing high K8/K18 levels are those predominantly recruited into the growing pool. This suggests that K8/K18 expression could constitute a novel factor regulating primordial follicle...
Source: Human Reproduction - February 1, 2018 Category: Reproduction Medicine Source Type: research

nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans
This study was supported by the National Natural Science Foundation of China (grant nos. 81370731, 31571551 and 31571190), the Science and Technology Project of Chongqing Education Committee (KJ130309), open funding by the Chongqing Institute for Family Planning (1201) and the Excellent Young Scholars of Chongqing Medical University (CQYQ201302). The authors have no conflicts of interest to declare.
Source: Human Reproduction - September 18, 2016 Category: Reproduction Medicine Authors: Zhang, X., Fu, L.-J., Liu, X.-Q., Hu, Z.-Y., Jiang, Y., Gao, R.-F., Feng, Q., Lan, X., Geng, Y.-Q., Chen, X.-M., He, J.-L., Wang, Y.-X., Ding, Y.-B. Tags: Reproductive biology Source Type: research

Interleukin-1 receptor antagonist mediates toll-like receptor 3-induced inhibition of trophoblast adhesion to endometrial cells in vitro
This study has been only done in vitro. Future in vivo studies will confirm our data. WIDER IMPLICATIONS OF THE FINDINGS The findings of this study have a potential clinical application in introducing IL-1RA as one of the diagnostic infertility markers in the endometrium, which can affect the process of embryo adhesion at the time of implantation. Moreover, based on the novel data obtained in the current study, blocking and regulating the MAPK pathway by its inhibitors can be used as a new strategy to prevent and treat virus-induced infertility cases in ART techniques. STUDY FUNDING/COMPETING INTEREST This study was part...
Source: Human Reproduction - August 18, 2016 Category: Reproduction Medicine Authors: Montazeri, M., Sanchez-Lopez, J. A., Caballero, I., Maslehat Lay, N., Elliott, S., Fazeli, A. Tags: Reproductive biology Source Type: research

Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes
STUDY QUESTION Does Sirt3 dysfunction result in poor developmental outcomes for human oocytes after in vitro maturation (IVM)? SUMMARY ANSWER Inefficient Sirt3 expression induced decreased mitochondrial DNA copy number and biogenesis, and therefore impaired the developmental competence of human IVM oocytes. WHAT IS KNOWN ALREADY Cytoplasmic immaturity in IVM oocytes may lead to reduced developmental competence. Mitochondrial dysfunction results in the accumulation of free radicals and leads to DNA mutations, protein damage, telomere shortening and apoptosis. SIRT3 (in the Sirtuin protein family) has emerged as a mitochon...
Source: Human Reproduction - February 16, 2016 Category: Reproduction Medicine Authors: Zhao, H.-C., Ding, T., Ren, Y., Li, T.-J., Li, R., Fan, Y., Yan, J., Zhao, Y., Li, M., Yu, Y., Qiao, J. Tags: Reproductive biology Source Type: research

Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL
This study used the human extravillous trophoblast-derived cell line SGHPL-4 cells. All experiments were performed at least three times. PARTICIPANTS/MATERIALS, SETTING, METHODS The effect of DDAH on trophoblast apoptosis was examined using siRNA and time-lapse microscopy. Changes in the expression of DDAH were followed by PCR and western blot analysis. Receptor expression was followed by flow cytometry. MAIN RESULTS AND THE ROLE OF CHANCE Inhibiting the expression of DDAH1, but not DDAH2, resulted in a significant increase in the sensitivity of the EVT cell line SGHPL-4 to tumour necrosis factor related apoptosis induci...
Source: Human Reproduction - July 19, 2015 Category: Reproduction Medicine Authors: Lumicisi, B. A., Cartwright, J. E., Leslie, K., Wallace, A. E., Whitley, G. S. Tags: Early pregnancy Source Type: research

MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos
STUDY QUESTION Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation? SUMMARY ANSWER Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts. WHAT IS KNOWN ALREADY The Let-7a microRNA is up-regulated during blastocyst dormancy and its forced-expression suppresses embryo implantation in vitro and in vivo. Dicer is a Let-7 target, which processes pre-microRNA to mature microRNA. STUDY DESIGN, SIZE, DURATION The effects on the expression of Let-7a and dicer in d...
Source: Human Reproduction - March 11, 2014 Category: Reproduction Medicine Authors: Cheong, A. W. Y., Pang, R. T. K., Liu, W.-M., Kottawatta, K. S. A., Lee, K.-F., Yeung, W. S. B. Tags: Reproductive biology Source Type: research

Identification of CD147 (basigin) as a mediator of trophoblast functions
STUDY QUESTION Does CD147 regulate trophoblast functions in vitro? SUMMARY ANSWER CD147 exists as a receptor complex on human trophoblast and regulates the implantation, invasion and differentiation of trophoblast. WHAT IS KNOWN ALREADY CD147 is a membrane protein implicated in a variety of physiological and pathological conditions due to its regulation of cell–cell recognition, cell differentiation and tissue remodeling. Reduced placental CD147 expression is associated with pre-eclampsia, but the mechanism of actions remains unclear. STUDY DESIGN, SIZE, DURATION A loss of function approach or functional blocking ...
Source: Human Reproduction - October 11, 2013 Category: Reproduction Medicine Authors: Lee, C.-L., Lam, M. P. Y., Lam, K. K. W., Leung, C. O. N., Pang, R. T. K., Chu, I. K., Wan, T. H. L., Chai, J., Yeung, W. S. B., Chiu, P. C. N. Tags: Early pregnancy Source Type: research

ER{beta}-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
STUDY QUESTION What are the in vitro effects of estrogen receptor β (ERβ) activation on the function of endothelial cells (ECs) from different vascular beds: human endometrial ECs (HEECs; endometrium), uterine myometrial microvascular ECs (UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)? SUMMARY ANSWER Studies conducted in vitro demonstrate that the ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression and network formation. Identification of a key role for the transcription factor Sp1 in ERβ-dependent signaling in uterine ECs o...
Source: Human Reproduction - August 21, 2013 Category: Reproduction Medicine Authors: Greaves, E., Collins, F., Critchley, H. O. D., Saunders, P. T. K. Tags: Reproductive biology Source Type: research