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Suppression of VEGF by Reversible-PEGylated Histidylated Polylysine in Cancer Therapy.
Abstract A reversible-PEGylated polylysine is designed and developed for efficient delivery of siRNA. In this unique structure, the ε-amino groups of disulfide linked poly(ethylene glycol) (PEG) and polylysine (mPEG-SS-PLL) are partially replaced by histidine groups, in order to develop the histidylated reversible-PEGylated polylysine (mPEG-SS-PLH), for enhanced endosome escape ability. The transfection efficacy of mPEG-SS-PLH is found to closely correlate with histidine substitution. Its maximum transfection efficiencies are determined, respectively, to be 75%, 42%, and 24%, against 293T, MCF-7, and PC-3 cells. ...
Source: Adv Data - May 7, 2014 Category: Epidemiology Authors: Cai X, Zhu H, Dong H, Li Y, Su J, Shi D Tags: Adv Healthc Mater Source Type: research