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Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma
Adv Sci (Weinh). 2023 Apr 21:e2207010. doi: 10.1002/advs.202207010. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic ...
Source: Adv Data - April 21, 2023 Category: Epidemiology Authors: Seok-Yeong Yu Yi Luan Siyuan Tang Amirhossein Abazarikia Rosemary Dong Thomas C Caffrey Michael A Hollingsworth David Oupicky So-Youn Kim Source Type: research