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Specialty: Epidemiology
Drug: Actos
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Total 1 results found since Jan 2013.
Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
Conclusions:
Pioglitazone inhibits VSMCs proliferation and promotes apoptosis of VSMCs through a PPARgamma signaling pathway. Up-regulation of caspase 3 and down-regulation of cyclins mediates pioglitazone's anti-proliferative and pro-apoptotic effects. Our results imply that pioglitazone prevents the VSMCs proliferation via modulation of caspase and cyclin signaling pathways in a PPARgamma-dependent manner.
Source: Epidemiologic Perspectives and Innovations - September 19, 2014 Category: Epidemiology Authors: Jing WanZhichao XiaoShengping ChaoShixi XiongXuedong GanXuguang QiuChang XuYexin MaXin Tu Source Type: research
