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Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma
Adv Sci (Weinh). 2023 Apr 21:e2207010. doi: 10.1002/advs.202207010. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic ...
Source: Adv Data - April 21, 2023 Category: Epidemiology Authors: Seok-Yeong Yu Yi Luan Siyuan Tang Amirhossein Abazarikia Rosemary Dong Thomas C Caffrey Michael A Hollingsworth David Oupicky So-Youn Kim Source Type: research

p38alpha MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine
Conclusion: Our results show that BBR inhibits proliferation and induces apoptosis of NSCLC cells through activation of p38alpha MAPK signaling pathway, followed by induction of the protein expression of p53 and FOXO3a. The latter contribute to the BBR-increased p21 (CIP1/WAF1) protein expression. The exogenous FOXO3a, interaction and mutually exclusive events of p53 and FOXO3a augment the overall response of BBR.
Source: Epidemiologic Perspectives and Innovations - April 26, 2014 Category: Epidemiology Authors: Fang ZhengQin TangJingJing WuShunYu ZhaoZhanYang LiangLiuning LiWanYin WuSwei Hann Source Type: research