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Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug
Conclusions: Cumulatively, these results signify a crucial role of the anti-inflammatory agent aspirin as a novel negative regulator of epithelial-to-mesenchymal transition thereby suggesting its candidature as a promising tool for deterring metastasis of highly invasive K-ras-expressing NSCLC cells.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Poulami KhanArgha MannaShilpi SahaSuchismita MohantyShravanti MukherjeeMinakshi MazumdarDeblina GuhaTanya Das Source Type: research

EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
Conclusions: The PEI nanocomplex fabricated with EpApt and siEp was able to target EpCAM tumor cells, deliver the siRNA and silence the target gene. This nanocomplex exhibited decreased cell proliferation than the scrambled aptamer loaded nanocomplex in the EpCAM expressing cancer cells and may have potential for EpCAM targeting in vivo.
Source: Epidemiologic Perspectives and Innovations - January 9, 2015 Category: Epidemiology Authors: Nithya SubramanianJagat R KanwarPrasanna AthalyaNarayanan JanakiramanVikas KhetanRupinder K KanwarSailaja EluchuriSubramanian Krishnakumar Source Type: research

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer
Conclusions: Our approach has identified genes required for the migration and invasion of metastatic tumor cells, and we propose that our new in vivo model system will be a powerful tool to interrogate the metastatic cascade in prostate cancer.
Source: Epidemiologic Perspectives and Innovations - May 30, 2014 Category: Epidemiology Authors: Jacqueline BanyardIvy ChungMatthew MigliozziDerek T PhanArianne M WilsonBruce R ZetterDiane R Bielenberg Source Type: research