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Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney
Caveolin 1 (CAV-1) functions not only as a constitutive scaffolding protein of caveolae but also as a vesicular transporter and signaling regulator. In the present study, we tested the hypothesis that CAV-1 knockout (CAV-1 KO) inhibits ANG II type 1 [AT1 (AT1a)] receptor-mediated uptake of ANG II in the proximal tubule and attenuates blood pressure responses in ANG II-induced hypertension. To determine the role of CAV-1 in mediating the uptake of FITC-labeled ANG II, wild-type (WT) mouse proximal convoluted tubule cells were transfected with CAV-1 small interfering (si)RNA for 48 h before AT1 receptor-mediated uptake of FI...
Source: AJP: Renal Physiology - October 15, 2014 Category: Urology & Nephrology Authors: Li, X. C., Gu, V., Miguel-Qin, E., Zhuo, J. L. Tags: ARTICLES Source Type: research

Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney.
Abstract Caveolin 1 (CAV-1) functions not only as a constitutive scaffolding protein of caveolae but also as a vesicular transporter and signaling regulator. In the present study, we tested the hypothesis that CAV-1 knockout (CAV-1 KO) inhibits AT1 (AT1a) receptor-mediated uptake of angiotensin II (ANG II) in the proximal tubule and attenuates blood pressure responses in ANG II-induced hypertension. To determine the role of CAV-1 in mediating the uptake of fluorescein (FITC)-labeled ANG II, wild-type (WT) mouse PT cells (mPCT) were transfected with CAV-1 siRNA for 48 h before AT1a-mediated uptake of FITC-ANG II wa...
Source: Am J Physiol Renal P... - August 27, 2014 Category: Urology & Nephrology Authors: Li XC, Gu V, Miguel-Qin E, Zhuo JL Tags: Am J Physiol Renal Physiol Source Type: research