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Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer
Conclusion: These findings suggest that both the mTOR pathway downstream of eukaryotic initiation factor 4E and S6K1 can be successfully inhibited, therefore, the recurrence of bladder cancer can be prevented by high-dose rapamycin only, suggesting that 4E-BP1 might be still under mTORC1.
Source: Urologic Oncology: Seminars and Original Investigations - November 18, 2013 Category: Urology & Nephrology Authors: Jong Kyou Kwon, Soon-Ja Kim, Jung Hoon Kim, Kyung Mee Lee, In Ho Chang Tags: Abstracts for Online Original Articles and Reviews Source Type: research

The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia
Conclusions: Our results demonstrate that Vav3 plays a crucial role in prostate cancer growth and malignant behavior, thus revealing a novel potential therapeutic target.
Source: Urologic Oncology: Seminars and Original Investigations - February 11, 2013 Category: Urology & Nephrology Authors: Kenichi Hirai, Takeo Nomura, Mutsushi Yamasaki, Toru Inoue, Takahiro Narimatsu, Ph.D. Chisato Nakada, Ph.D. Yoshiyuki Tsukamoto, Keiko Matsuura, Fuminori Sato, Masatsugu Moriyama, Hiromitsu Mimata Tags: Clinical - Prostate Source Type: research

The Role of Hypoxia-Inducible Factor-1α and -2α in Androgen Insensitive Prostate Cancer Cells
Conclusions: Our results demonstrate that HIF-1α and -2α are important for cell proliferation and invasion ability in prostate cancer. Together, our results indicate that combinations of target agents with HIF knockdown may represent a promising strategy for the treatment of prostate cancer.
Source: Urologic Oncology: Seminars and Original Investigations - April 27, 2012 Category: Urology & Nephrology Authors: Chang Wook Jeong, Cheol Yong Yoon, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Cheol Kwak, Sang Eun Lee Tags: Clinical - Prostate Source Type: research

Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development
Conclusions: Slug elevates in invasive or metastatic bladder cancer and plays a critical role in EMT via control of cadherin switch. Slug may be a potential marker or target for improving the diagnosis and treatment of muscle-invasive bladder cancers.
Source: Urologic Oncology: Seminars and Original Investigations - March 16, 2012 Category: Urology & Nephrology Authors: Kaijie Wu, Jin Zeng, Jiancheng Zhou, Jinhai Fan, Yule Chen, Zhiqiang Wang, TingTing Zhang, Xinyang Wang, Dalin He Tags: Laboratory - Bladder Source Type: research

The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor
Conclusions: Our study suggests reciprocal regulation of PlncRNA-1 and androgen receptor contribute to CaP pathogenesis and that PlncRNA-1 is a potential therapy target.
Source: Urologic Oncology: Seminars and Original Investigations - January 24, 2012 Category: Urology & Nephrology Authors: Zilian Cui, Shancheng Ren, Ji Lu, Fubo Wang, Weidong Xu, Yi Sun, Min Wei, Junyi Chen, Xu Gao, Chuanliang Xu, Jian-Hua Mao, Yinghao Sun Tags: Laboratory - Prostate Source Type: research

NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma
Conclusions: Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines. These might provide a basis for the designing new therapeutic strategies for CCRCC.
Source: Urologic Oncology: Seminars and Original Investigations - October 13, 2011 Category: Urology & Nephrology Authors: Shangwen Liu, Xin Ma, Qing Ai, Qingbo Huang, Taoping Shi, Mingyang Zhu, Baojun Wang, Xu Zhang Tags: Clinical - Kidney Source Type: research

Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells
Conclusions: Silencing of HSP70 expression using siRNA could be an attractive therapeutic strategy for bladder cancer by inducing inhibition of tumor growth as well as enhancing chemosensitivity.
Source: Urologic Oncology: Seminars and Original Investigations - September 5, 2011 Category: Urology & Nephrology Authors: Hosny M. Behnsawy, Hideaki Miyake, Yuji Kusuda, Masato Fujisawa Tags: Clinical - Bladder Source Type: research

Small interference RNA-mediated silencing of prostate stem cell antigen attenuates growth, reduces migration and invasion of human prostate cancer PC-3M cells
Conclusions: The present study provides the first evidence that silencing PSCA using siRNA can inhibit the proliferation and invasiveness properties of human CaP cells, which may provide a promising therapeutic strategy for CaP and open a novel avenue toward the investigation of the role of PSCA overexpression in cancers.
Source: Urologic Oncology: Seminars and Original Investigations - March 24, 2011 Category: Urology & Nephrology Authors: Zhigang Zhao, Wenjing Ma, Guohua Zeng, Defeng Qi, Lili Ou, Yeping Liang Tags: Clinical - Prostate Source Type: research