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Specialty: Urology & Nephrology
Source: The Prostate
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Total 35 results found since Jan 2013.
Validation of histone deacetylase 3 as a therapeutic target in castration ‐resistant prostate cancer
ConclusionsOur studies provide strong rationale for the near‐term development of specific HDAC3 inhibitors for the treatment of CRPC.
Source: The Prostate - December 15, 2017 Category: Urology & Nephrology Authors: Abigail B. McLeod, James P. Stice, Suzanne E. Wardell, Holly M. Alley, Ching ‐yi Chang, Donald P. McDonnell Tags: ORIGINAL ARTICLE Source Type: research
TRAF6 regulates proliferation of stromal cells in the transition and peripheral zones of benign prostatic hyperplasia via Akt/mTOR signaling
ConclusionsTRAF6 can promote the proliferation of stromal cells of BPH via Akt/mTOR signaling. Our results may make stromal TRAF6 responsible for zonal characteristic of BPH and as a promising therapeutic strategy for BPH treatment.
Source: The Prostate - November 24, 2017 Category: Urology & Nephrology Authors: Yun ‐Feng Shi, Dian‐Jun Yu, Chen‐Yi Jiang, Xing‐Jie Wang, Yi‐Ping Zhu, Rui‐Zhe Zhao, Zhong Lv, Xiao‐Wen Sun Tags: ORIGINAL ARTICLE Source Type: research
The orally active pterocarpanquinone LQB ‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
ConclusionLQB‐118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB‐118 activity, presumably by impairing the cellular antioxidant response.
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Thiago Martino, Tarana A. Kudrolli, Binod Kumar, Isis Salviano, Andr é Mencalha, Marsen Garcia P. Coelho, Graça Justo, Paulo R. Ribeiro Costa, Kátia C. Carvalho Sabino, Shawn E. Lupold Tags: ORIGINAL ARTICLE Source Type: research
Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals
CONCLUSIONSSHARPIN enhances the metastasis of prostate cancer and impair patient survivals. Prostate. © 2017 Wiley Periodicals, Inc.
Source: The Prostate - February 23, 2017 Category: Urology & Nephrology Authors: Hai Huang, Tao Du, Yiming Zhang, Yiming Lai, Kaiwen Li, Xinxing Fan, Dingjun Zhu, Tianxin Lin, Kewei Xu, Jian Huang, Leyuan Liu, Zhenghui Guo Tags: Original Article Source Type: research
Androgen Receptor Splice Variants Are Not Substrates of Nonsense ‐Mediated Decay
CONCLUSIONThis study eliminates a possible mechanism of regulation of certain AR variants. Future research into the regulation of AR variants should focus on other mechanisms to better understand the origin of these variants and to possibly inhibit their expression for the resensitization of resistant cancers. Prostate. © 2017 Wiley Periodicals, Inc.
Source: The Prostate - February 22, 2017 Category: Urology & Nephrology Authors: Atinuke S. Ajiboye, David Esopi, Srinivasan Yegnasubramanian, Samuel R. Denmeade Tags: Original Article Source Type: research
Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research
Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters
CONCLUSIONSNew CRPC cell line with increased expression of y+LAT2 as a leucine transporter was established in vitro. Anti‐leucine transporter therapy could be an important option against prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - October 3, 2016 Category: Urology & Nephrology Authors: Hideo Otsuki, Toru Kimura, Takashi Yamaga, Takeo Kosaka, Jun ‐ichi Suehiro, Hiroyuki Sakurai Tags: Original Article Source Type: research
TGF ‐β Effects on Prostate Cancer Cell Migration and Invasion Require FosB
CONCLUSIONOur data suggest that FosB is required for migration and invasion in prostate cancer cells. We also conclude that TGF‐β1 effect on prostate cancer cell migration and invasion may be mediated through the induction of FosB. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - September 8, 2016 Category: Urology & Nephrology Authors: Cach étne S.X. Barrett, Ana C. Millena, Shafiq A. Khan Tags: Original Article Source Type: research
Metformin elicits antitumor effects and downregulates the histone methyltransferase multiple myeloma SET domain (MMSET) in prostate cancer cells
CONCLUSIONSThese data suggest MMSET may play a role in the inhibitory effect of metformin on PCa and could serve as a potential novel therapeutic target for PCa. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - July 11, 2016 Category: Urology & Nephrology Authors: Nicole M. A. White‐Al Habeeb, Julia Garcia, Neil Fleshner, Bharati Bapat Tags: Original Article Source Type: research
AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth
ConclusionsLow AXIN2 expression was associated with PCa recurrence after RP in our test population as well as in external validation cohorts, and its expression levels in PCa cells significantly impacted invasiveness, proliferation, and tumor growth. Given these novel roles, further study of AXIN2 in PCa may yield promising new predictive and therapeutic strategies. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - January 15, 2016 Category: Urology & Nephrology Authors: Brian R. Hu, Adrian S. Fairey, Anisha Madhav, Dongyun Yang, Meng Li, Susan Groshen, Craig Stephens, Philip H. Kim, Navneet Virk, Lina Wang, Sue Ellen Martin, Nicholas Erho, Elai Davicioni, Robert B. Jenkins, Robert B. Den, Tong Xu, Yucheng Xu, Inderbir S. Tags: Original Article Source Type: research
Lin28 induces resistance to anti‐androgens via promotion of AR splice variant generation
ConclusionsOur findings suggest that Lin28 plays a key role in the acquisition of resistance to AR‐targeted therapies by PCa cells and establish the importance of Lin28 in PCa progression. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - December 30, 2015 Category: Urology & Nephrology Authors: Ramakumar Tummala, Nagalakshmi Nadiminty, Wei Lou, Christopher P. Evans, Allen C. Gao Tags: Original Article Source Type: research
RNA interference targeting PSCA suppresses primary tumor growth and metastasis formation of human prostate cancer xenografts in SCID mice
ConclusionsTaken together, these observations suggest that PSCA has a promoting role in the growth and metastasis of PCa and siRNA‐PSCA may be a potential therapeutic strategy for PSCA‐positive PCa. Prostate 9999: 1–15, 2015. © 2015 Wiley Periodicals, Inc.
Source: The Prostate - October 19, 2015 Category: Urology & Nephrology Authors: Zhigang Zhao, Jun He, Ran Kang, Shankun Zhao, Luhao Liu, Futian Li Tags: Original Article Source Type: research
Relationship between serum response factor and androgen receptor in prostate cancer
CONCLUSIONOur data support SRF as a promising therapeutic target in combination with current treatments. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - August 7, 2015 Category: Urology & Nephrology Authors: Maria Prencipe, Amanda O'Neill, Gillian O'Hurley, Lan K. Nguyen, Aurelie Fabre, Anders Bjartell, William M. Gallagher, Colm Morrissey, Elaine W. Kay, R. William Watson Tags: Original Article Source Type: research
KDM1A triggers androgen‐induced miRNA transcription via H3K4me2 demethylation and DNA oxidation
ConclusionOur work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen‐dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - March 2, 2015 Category: Urology & Nephrology Authors: Shu Yang, Jiyuan Zhang, Yalong Zhang, Xuechao Wan, Congzhe Zhang, Xiaohui Huang, Wenhua Huang, Honglei Pu, Chaohan Pei, Hai Wu, Yan Huang, Shengdong Huang, Yao Li Tags: Original Article Source Type: research
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer
CONCLUSIONSTaken together, our data supports the assertion that epigenetic modification of the ITGA2 promoter is a mechanism by which ITGA2 expression is regulated. Prostate 9999: XX–XX, 2014. © 2015 Wiley Periodicals, Inc.
Source: The Prostate - February 7, 2015 Category: Urology & Nephrology Authors: Suyin Paulynn Chin, James R. Marthick, Alison C. West, Annabel K. Short, Jyoti Chuckowree, Andrea M. Polanowski, Russell J. Thomson, Adele F. Holloway, Joanne L. Dickinson Tags: Original Article Source Type: research
