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Specialty: Urology & Nephrology
Cancer: Head and Neck Cancer
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Total 6 results found since Jan 2013.
Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury
Am J Physiol Renal Physiol. 2022 Jul 14. doi: 10.1152/ajprenal.00229.2021. Online ahead of print.ABSTRACTCisplatin is an established chemotherapeutic drug for treatment of solid-organ cancers, and is the primary drug utilized in the treatment of head and neck cancer; however, cisplatin-induced nephrotoxicity largely limits its clinical use. Inhibition of sphingosine kinase 2 (SphK2) has been demonstrated to alleviate various kidney diseases. Therefore, we hypothesized that inhibition of SphK2 could also protect against cisplatin-induced nephrotoxicity. Results from the present study showed that the SphK2 inhibitor, ABC2946...
Source: Am J Physiol Renal P... - July 14, 2022 Category: Urology & Nephrology Authors: Dengpiao Xie Gaizun Hu Chaoling Chen Fereshteh Ahmadinejad Weili Wang Pin-Lan Li David A Gewirtz Ningjun Li Source Type: research
