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Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo
ConclusionUTMD enhanced the radiosensitivity of glioblastoma partially by disrupting PGRMC1-mediated autophagy.
Source: Military Medical Research - February 14, 2022 Category: International Medicine & Public Health Source Type: research

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood –brain barrier injury through the Wnt/β-catenin signalling pathway
ConclusionThis study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/ β-catenin signalling pathway under ischemic conditions.
Source: Military Medical Research - December 3, 2021 Category: International Medicine & Public Health Source Type: research

Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
ConclusionIt is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.
Source: Military Medical Research - November 10, 2021 Category: International Medicine & Public Health Source Type: research

RIG-I, a novel DAMPs sensor for myoglobin, activates NF- κB/caspase-3 signaling in CS-AKI model
ConclusionRIG-I is a novel damage-associated molecular patterns (DAMPs) sensor for myoglobin and participates in the NF- κB/caspase-3 signaling pathway in CS-AKI. In the development of CS-AKI, specific intervention in the RIG-I pathway might be a potential therapeutic strategy for CS-AKI.
Source: Military Medical Research - June 21, 2021 Category: International Medicine & Public Health Source Type: research

RIG-I, a novel DAMPs sensor for myoglobin activates NF- κB/caspase-3 signaling in CS-AKI model
ConclusionRIG-I is a novel damage-associated molecular patterns (DAMPs) sensor for myoglobin and participates in the NF- κB/caspase-3 signaling pathway in CS-AKI. In the development of CS-AKI, specific intervention in the RIG-I pathway might be a potential therapeutic strategy for CS-AKI.
Source: Military Medical Research - June 21, 2021 Category: International Medicine & Public Health Source Type: research